Efforts to Improve the Images from 67 Ga Whole-Body Scintigraphy
Kyoko Saito,Yasuyuki Takahashi,Naomi Ogano,Hirotaka Shimada,Takao Kanzaki,Hiroki Okada,Kei Yokota,Kaori Hatano,Yuki Yoshida,Tetsuya Higuchi +9 more
TLDR
In this study, steps to optimize the acquisition method, and to choose a scatter correction, are taken to improve image quality and diagnostic accuracy for planar 67Ga imaging.Abstract:
The
acquisition method for planar 67Ga imaging has hardly changed for 30
years. In this study, in order to improve image quality and diagnostic accuracy,
we take steps to optimize the acquisition method, and to choose a scatter
correction. First, we acquired individual images from the 93 keV, 185 keV, and
300 keV photopeak; then the images were added together and compared to the
individual images. Second, we compared results from a low-medium-energy (LME)
collimator with those from a conventional medium-energy (ME) collimator. Also,
we examined whether to combine the data from all three of the usual window
locations (set about 93 keV, 185 keV, and 300 keV) or to use the data from only
two. Third, we compared results from a conventional photopeak ± 10% window with those from a
photopeak ± 9 keV window. Fourth, for scatter correction we compared results
using the triple energy window (TEW) method with those using the multi-photopeak
dual window (MDW) method. The phantoms studied were cold rods in a uniform
background, and hot spheres within a cylinder containing uniformly radioactive
water. The clinical study involved 22 patients with lung lesions. By the
comparison by the contrast ratio in cold rods phantom, 15.6% is improved in LME
(2 peaks) than ME (3 peaks), and 3.2% is improved in photopeak ± 9 keV than
photopeak ± 10%, 10.2% is improved in TEW than MDW. However, the TEW scatter
correction method recognized unstable to the contrast ratio in a clinical
study. In addition, a body outline might disappear.read more
References
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Journal ArticleDOI
Simulation study of triple-energy-window scatter correction in combined Tl-201, Tc-99m SPECT.
TL;DR: The triple energy window (TEW) method was applied to a multiradionuclide SPECT study and its effect was examined in a simulation study, giving good agreement between the activity distributions reconstructed from primary photons and those from corrected data.
Journal ArticleDOI
Evaluating the possible role of 68Ga-citrate PET/CT in the characterization of indeterminate lung lesions.
Mariza Vorster,Alex Maes,Aldrich Jacobs,Sidney Malefahlo,Hans Pottel,Christophe Van de Wiele,Machaba Sathekge +6 more
TL;DR: This study, as the first 68Ga-citrate PET/CT in humans for the in vivo imaging of lung pathology, demonstrated its potential for the detection of both malignancy and TB and seemed incapable of providing a clear distinction between malignant and benign lung lesions.
Journal ArticleDOI
Acquisition Protocols and Correction Methods for Estimation of the Heart-to-Mediastinum Ratio in 123I-Metaiodobenzylguanidine Cardiac Sympathetic Imaging
Yusuke Inoue,Yutaka Abe,Yoshihiro Itoh,Yuji Asano,Kei Kikuchi,Yutaka Sakamoto,Keiji Matsunaga,Yutaka Ogino,Takahiro Iizuka,Hideki Mochizuki +9 more
TL;DR: The use of an LME collimator appears to be acceptable for cardiac 123I-MIBG imaging as an alternative to an ME collimATOR, and the application of a 15% energy window is recommended when an Lme collimators is used.