Journal ArticleDOI
Electrochemical Studies on Minoxidil and Its Determination in Tablets by Differential-Pulse Polarography.
TLDR
Good agreement was obtained between results with the differential-pulse polarography method and those by the manufacturer's method of assay, which involves the transfer of four electrons as well as dehydration and deamination steps in acid solution.Abstract:
A simple differential-pulse polarographic method has been developed for the determination of minoxidil in pharmaceutical dosage forms. The extracting solvent was methanol and the supporting electrolyte was 1.0 N sulphuric acid. An excellent linear relationship was obtained between the concentration and current peak height with a correlation coefficient of 0.9999. Good agreement was obtained between results with the differential-pulse polarography method and those by the manufacturer's method of assay. There was no interference by the tablet excipients. In acid solution, a mechanism for reduction at –1.2 V is proposed, which involves the transfer of four electrons as well as dehydration and deamination steps.read more
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Journal ArticleDOI
Computational design and development of a novel voltammetric sensor for minoxidil detection based on electropolymerized molecularly imprinted polymer
TL;DR: In this article, a novel electrochemical sensor based on molecularly imprinted polymer (MIP) with sensitive and selective binding sites for minoxidil (MX) were developed.
Journal ArticleDOI
Fast and accurate analysis of drugs using amperometry associated with flow injection analysis.
Fabiana S. Felix,Lúcio Angnes +1 more
TL;DR: Fundamental aspects, developments, applications and advantages accrued from the coupling of voltammetry with FIA for pharmaceutical analyses are discussed and the selected references present several examples for this association in various classes of drugs.
Journal ArticleDOI
Electrochemical determination of minoxidil in different pharmaceutical formulations by flow injection analysis
TL;DR: The accuracy of FIA-amperometric method was established by a comparison with the conventional UV determination technique using a paired t-test indicating the absence of systematic errors.
Journal ArticleDOI
Integrated flow injection-solid phase spectrophotometric determination of minoxidil.
TL;DR: The method was satisfactorily applied to the determination of minoxidil in pharmaceutical preparations and the results were compared with those obtained by high performance liquid chromatography (HPLC).
Journal ArticleDOI
Simultaneous spectrophotometric determination of minoxidil and tretinoin by the H-point standard addition method and partial least squares
Maryam Bordbar,Ali Yeganeh-Faal,Jahanbakhsh Ghasemi,Mohammad Mahdi Ahari-Mostafavi,Nahid Sarlak,Mohammad Taghi Baharifard +5 more
TL;DR: In this paper, a simple, sensitive and selective spectrophotometric method for simultaneous determination of tretinoin and minoxidil using partial least square (PLS) calibration and H-point standard addition method (HPSAM) is described.