Journal ArticleDOI
Enantioselective synthesis of β-hydroxy-α-methyl carbonyl compounds by aldol reaction
A. Ando,Takayuki Shioiri +1 more
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TLDR
The enantioselective aldol reactions of ketone lithium enolates with aldehydes mediated chiral lithium amides were extensively investigated in this paper, where the chiral amino ethers 4a, 4l and diamines 16a, b were prepared from α-amino acids.About:
This article is published in Tetrahedron.The article was published on 1989-01-01. It has received 37 citations till now. The article focuses on the topics: Aldol reaction & Enantiomeric excess.read more
Citations
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Asymmetric synthesis using homochiral lithium amide bases
P. J. Cox,Nigel S. Simpkins +1 more
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Reductive Aminations of Carbonyl Compounds with Borohydride and Borane Reducing Agents
Ellen W. Baxter,Allen B. Reitz +1 more
TL;DR: A review of reductive aminations using borohydride and borane reducing agents can be found in this article, where the authors focus on those conditions in which the carbonyl component, amine, and reducing reagent react in the same vessel.
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BINAP/AgOTf/KF/18-crown-6 as new bifunctional catalysts for asymmetric Sakurai-Hosomi allylation and Mukaiyama aldol reaction.
TL;DR: A catalytic amount of KF.18-crown-6 complex is effective as a soluble fluoride source to activate an asymmetric Sakurai-Hosomi allylation with BINAP and silver(I) triflate catalyst, resulting in high yields and remarkable enantioselectivities.
References
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Journal ArticleDOI
Cyanohydridoborate anion as a selective reducing agent
TL;DR: The use of modified boron hydrides as selective reducing agents for organic functional g roups has been studied extensively as discussed by the authors, with a focus on reducing a wide variety of organic functional groups with remarkable selectivity.
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Structure and Reactivity of Lithium Enolates. From Pinacolone to Selective C‐Alkylations of Peptides. Difficulties and Opportunities Afforded by Complex Structures
TL;DR: The chemistry of lithium enolates is used to demonstrate that complex structures held together by noncovalent bonds (supramolecules) may dramatically influence the result of seemingly simple standard reactions of organic synthesis as mentioned in this paper.
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Catalytic asymmetric aldol reaction: reaction of aldehydes with isocyanoacetate catalyzed by a chiral ferrocenylphosphine-gold(I) complex
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New Methods and Reagents in Organic Synthesis. 14. A Simple Efficient Preparation of Methyl Esters with Trimethylsilyldiazomethane (TMSCHN2) and Its Application to Gas Chromatographic Analysis of Fatty Acids
TL;DR: Trimethylsilyldiazomethane (TMSCHN2) was used in the Arndt-Eistert synthesis and homologation of carbonyl compounds.