Enhancement of perfusion reserve by cardiac resynchronization therapy: reply
Reads0
Chats0
TLDR
The letter from Dr Knaapen and co-workers raised an interesting and critical point about the conclusion that further studies have to clarify whether long-term cardiac resynchronization therapy (CRT) is able to improve myocardial perfusion and metabolism at a global level, suggesting a regression of cardiomyopathy.Abstract:
The letter from Dr Knaapen and co-workers raised an interesting and critical point about our conclusion that further studies have to clarify whether long-term cardiac resynchronization therapy (CRT) is able to improve myocardial perfusion and metabolism at a global level, suggesting a regression of cardiomyopathy. This conclusion was based on the observation that global resting MBF and MVO2, which were reduced in our cardiomyopathy patients, …read more
Citations
More filters
Journal ArticleDOI
The current role of cardiac resynchronization therapy in reducing mortality and hospitalization in heart failure patients: a meta-analysis from clinical trials
Andrea Rossi,Giuseppe Rossi,Marcello Piacenti,Umberto Startari,Luca Panchetti,Maria-Aurora Morales +5 more
TL;DR: A meta-analysis showed that patients with implantable cardiac defibrillators alone and ICD+CRT had a significant reduction of worsening HF hospitalization rate compared to no CRT-no ICD patients, and among patients with ICDs, CRT showed a slight effect on all-cause mortality reduction but no clear impact on worsening HF rehospitalization.
Book ChapterDOI
Nuclear Imaging for Device Therapy
Amparo L. Figueroa,Ahmed Tawakol +1 more
TL;DR: The potential role of nuclear imaging for device therapy is discussed and recent developments in cardiology research suggest that nuclear imaging may prove to be an important clinical tool for evaluating patients with cardiac electrophysiologic pathologies.
References
More filters
Journal ArticleDOI
The effects of cardiac resynchronization therapy on left ventricular function, myocardial energetics, and metabolic reserve in patients with dilated cardiomyopathy and heart failure
Jan Sundell,Erik Engblom,Juhani Koistinen,Antti Ylitalo,Alexandru Naum,Kira Q. Stolen,Riikka Kalliokoski,Stephan G. Nekolla,K.E. Juhani Airaksinen,Jeroen J. Bax,Juhani Knuuti +10 more
TL;DR: Long-term CRT has beneficial effects on LV function and myocardial efficiency at rest in patients with HF, and during dobutamine-induced stress, CRT does not affect functional parameters, but myocardian efficiency and metabolic reserve may be increased.
Journal ArticleDOI
Effects of Cardiac Resynchronization Therapy on Myocardial Perfusion Reserve
Paul Knaapen,Linda C.M.C. van Campen,Carel C. de Cock,Marco J.W. Götte,Cees A. Visser,Adriaan A. Lammertsma,Frans C. Visser +6 more
TL;DR: Resting MBF is unaltered by CRT despite an increase in left ventricular function, however, the distribution pattern of resting MBF becomes more homogeneous as demonstrated by the septal-to-lateral ratio.
Journal ArticleDOI
Effect of cardiac resynchronization therapy on global and regional oxygen consumption and myocardial blood flow in patients with non-ischaemic and ischaemic cardiomyopathy.
Oliver Lindner,Jürgen Vogt,A. Kammeier,Peter Wielepp,Jens Holzinger,D. Baller,Barbara Lamp,Bert Hansky,Reiner Körfer,Dieter Horstkotte,Wolfgang Burchert +10 more
TL;DR: CRT induces changes of MVO2 and MBF on a regional level with a more uniform distribution between the myocardial walls and improved ventricular efficiency in NICM, and appears to be more effective in NICm than in ICM.