Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas
Selcuk Demiral,Mehmet Murat Beyzadeoğlu,Ömer Sağer,Ferrat Dincoglan,Hakan Gamsiz,Bora Uysal,Kaan Oysul,Esin Gundem,Bahar Dirican,Sait Sirin +9 more
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TLDR
This study supports the usage of LINAC-based SRS as a safe and effective management strategy for patients with recurrent or residual craniopharyngiomas.Abstract:
Although benign histologically, craniopharyngiomas may display clinically malignant behavior with a strong propensity for recurrence. Contemporary therapeutic approaches for craniopharyngiomas include stereotactic irradiation in the form of Stereotactic Radiosurgery (SRS) or Fractionated Stereotactic Radiation Therapy (FSRT) as part of multimodality treatment particularly when complete surgical removal is not feasible. In this study, we evaluate the use of Linear Accelerator (LINAC)-based SRS in the multidisciplinary management of patients with craniopharyngiomas. Between July 1998 and July 2013, 20 patients (11 male, 9 female) with residual or recurrent craniopharyngiomas were treated using LINAC-based SRS at Department of Radiation Oncology, Gulhane Military Medical Academy. Median age was 37 (9-69) years. Median tumor volume was 1.1 (0.9-6.9) cc. Median dose was 13 Gy (range: 10-16 Gy) prescribed to the 80%-95% isodose line encompassing the target volume. Median follow-up time was 47 (7-93) months. Overall local control rate was 88% at 1 year, 79% at 3 years and 66% at 5 years. Three and 5-year progression free survival rates were 95% and 91% whereras 3 and 5-year overall survival rates were 94% and 88%, respectively. Our study supports the usage of LINAC-based SRS as a safe and effective management strategy for patients with recurrent or residual craniopharyngiomas.read more
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Hypofractionated stereotactic radiotherapy (HFSRT) for who grade I anterior clinoid meningiomas (ACM)
Selcuk Demiral,Ferrat Dincoglan,Omer Sager,Hakan Gamsiz,Bora Uysal,Esin Gundem,Yelda Elcim,Bahar Dirican,Murat Beyzadeoglu +8 more
TL;DR: LINAC-based HFSRT offers high rates of LC and PFS for patients with ACMs, and only two patients experienced clinical deterioration during the follow-up period.
Journal ArticleDOI
Contemporary Management of Meningiomas with Radiosurgery
Demiral Selcuk,Dincoglan Ferrat,Sager Omer,Uysal Bora,Gamsiz Hakan,Ozcan Fatih,Dirican Bahar,Beyzadeoglu Murat +7 more
TL;DR: Demiral et al. as mentioned in this paper described the contemporary management of Meningiomas with radiosurgery. But their work focused on the management of radiolabels, and not on the treatment of the MRIs.
Journal ArticleDOI
Radiosurgery for recurrent glioblastoma: a review article
Ferrat Dincoglan,Omer Sager,Selcuk Demiral,Bora Uysal,Hakan Gamsiz,Bahar Dirican,Murat Beyzadeoglu +6 more
TL;DR: The use of radiosurgery for management of recurrent GB is reviewed in light of the literature and several therapeutic strategies are employed in the recurrent setting with no established standard of care.
Journal ArticleDOI
Multimodality Imaging for Radiosurgical Management of Arteriovenous Malformations
TL;DR: Treatment planning for AVM radiosurgery may be improved by incorporating CT-MR fusion based imaging, which clearly should be supplemented with additional data from angiography.
Journal ArticleDOI
Evaluation of Radiosurgery Target Volume Determination for Meningiomas Based on Computed Tomography (CT) And Magnetic Resonance Imaging (MRI)
TL;DR: Improved target volume definition is a pertinent goal of optimal radiosurgical treatment planning for patients treated with radiosurgery for meningiomas and the utility of MRI inMeningioma radiosur surgery treatment planning is supported.
References
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Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients.
TL;DR: The results of this series suggest that primary total removal of craniopharyngiomas yields the best long-term outcome for the patient.
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The descriptive epidemiology of craniopharyngioma
Greta R. Bunin,Tanya S. Surawicz,Philip A. Witman,Susan Preston-Martin,Faith G. Davis,Janet M. Bruner +5 more
TL;DR: The incidence of craniopharyngioma in the United States was estimated from two population-based cancer registries that include brain tumors of benign and borderline malignancy and Los Angeles county and information on additional pediatric tumors was available from the Greater Delaware Valley Pediatric Tumor Registry.
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Aggressive surgical management of craniopharyngiomas in children
TL;DR: The cases of 50 patients with craniopharyngioma operated on at The Hospital for Sick Children in Toronto between January, 1975, and December, 1989, are reviewed and 28 are leading a normal or nearly normal life, although all are receiving endocrine replacement and some have required help to overcome mild deficits in memory or visual acuity.
Journal ArticleDOI
Gamma knife radiosurgery in the management of cavernous sinus meningiomas
Pierre-Hugues Roche,Jean Régis,Henry Dufour,Henri-Dominique Fournier,Christine Delsanti,William Pellet,François Grisoli,Jean-Claude Peragut +7 more
TL;DR: In this paper, the use of positron emission tomography (PET) as a stereotactic planning modality for gamma knife radiosurgery (GKS) was evaluated.
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Craniopharyngioma in adults and children: a study of 122 surgical cases
TL;DR: These results compared favorably with the data reported in the literature, suggesting that radical surgery of craniopharyngiomas allows good outcome in terms of survival, full recovery, and quality of life for both adults and children.