Extensive keloid scarring in a patient with pemphigus vulgaris
TLDR
A very atypical and unusual course of pemphigus vulgaris with extensive keloid formation despite high systemic steroids is described, promoted by the severe flare of the disease, the delay of scarring, and the superinfection.Abstract:
Since pemphigus blisters are intraepidermal, scarring should induce at most a post‐inflammatory hyperpigmentation. We describe a very atypical and unusual course of pemphigus vulgaris with extensive keloid formation despite high systemic steroids. This could be promoted by the severe flare of the disease, the delay of scarring, and the superinfection.read more
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Journal ArticleDOI
Mechanisms of Disease: Pemphigus and Bullous Pemphigoid.
TL;DR: Knowing the mechanisms of disease has enabled diagnostic testing for these diseases by enzyme-linked immunosorbent assays and dissection of various pathophysiological mechanisms, including direct inhibition of cell adhesion, antibody-induced internalization of antigen, and cell signaling.
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Keloids demonstrate high-level epidermal expression of vascular endothelial growth factor
TL;DR: The findings demonstrate that keloids are angiogenic lesions, and topical antiangiogenic therapy, directed at either down-regulating epidermal VEGF or inhibiting keratinocyte-derived V EGF activity on its endothelial receptors, may be useful in the treatment of keloid patients.
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Pemphigus vulgaris: accumulation of apoptotic cells in dermis and epidermis possibly relates to pathophysiology through TNF-alpha production by phagocytes.
TL;DR: Accumulation of apoptotic cells in PV could promote TNF-α production by monocytes, which could, in turn, cause further apoptosis, closing a vicious circle.
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Extensive keloids following cyclosporin therapy in a pemphigus vulgaris patient
TL;DR: A bullous and pruritic variant of disseminated superficial actinic porokeratosis: successful treatment with Grenz rays is presented.
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Unusual formation of keloids after each episode of recurrent herpes zoster in an HIV positive patient.
TL;DR: A rare case of recurrent HZ in an HIV-positive male where the lesions have healed with formation of keloids in both episodes.