J
John R. Stanley
Researcher at University of Pennsylvania
Publications - 92
Citations - 6797
John R. Stanley is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Pemphigus & Pemphigus vulgaris. The author has an hindex of 39, co-authored 92 publications receiving 6376 citations. Previous affiliations of John R. Stanley include National Institutes of Health.
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Journal ArticleDOI
Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin.
TL;DR: It is reported that fresh murine LC express cadherins, and that LC adhere to KC in vitro through E-cadherin, and to begin to elucidate mechanisms involved in LC trafficking, LC-keratinocyte (KC) interactions are characterized.
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Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris
My G. Mahoney,My G. Mahoney,Zhi Hong Wang,Kyle Rothenberger,Peter Koch,Peter Koch,Masayuki Amagai,John R. Stanley +7 more
TL;DR: It is suggested that pemphigus autoantibodies inhibit the adhesive function of desmoglein proteins, and it is demonstrated that either Dsg1 or Dsg3 alone is sufficient to maintain keratinocyte adhesion.
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Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1
TL;DR: It is shown here that exfoliative toxin A cleaved mouse and human Dsg1, but not closely related cadherins such as Dsg3.
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Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris
Peter Koch,My G. Mahoney,Hiroyasu Ishikawa,Leena Pulkkinen,Jouni Uitto,Leonard Shultz,George F. Murphy,Diana Whitaker-Menezes,John R. Stanley +8 more
TL;DR: It is suggested that pemphigus autoantibodies might interfere directly with such a function of DSG3, and the critical importance of Dsg3 for adhesion in deep stratified squamous epithelia is demonstrated.
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Pemphigus, Bullous Impetigo, and the Staphylococcal Scalded-Skin Syndrome
John R. Stanley,Masayuki Amagai +1 more
TL;DR: The clinical and pathological similarities among these forms of pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome are discussed.