Patent
Fast dissolving tablet and its production
TLDR
In this article, a method of producing a fast dissolving tablet comprising compression-molding a composition comprising an active ingredient, a carbohydrate and a barely sufficient amount of water to moisten the surface of particles of said carbohydrate into a tablet form and obtainable by the method.Abstract:
A method of producing a fast dissolving tablet comprising compression-molding a composition comprising an active ingredient, a carbohydrate and a barely sufficient amount of water to moisten the surface of particles of said carbohydrate into a tablet form and a fast dissolving tablet obtainable by the method. The active ingredient may for example be a vitamin, a gastrointestinal function conditioning agent or an antipyretic-analgesic-antiinflammatory agent. The carbohydrate includes sugar, starch sugars, lactose, honey, sugar alcohols and tetroses. The amount of water to be added is about 0.3 to 10% by weight. The above fast dissolving tablet has a porous structure with excellent disintegratability and solubility as well as adequate strength.read more
Citations
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Journal ArticleDOI
Orally fast disintegrating tablets: developments, technologies, taste-masking and clinical studies.
TL;DR: This review describes in detail FDT technologies based on lyophilization, molding, sublimation, and compaction, as well as approaches to enhancing the FDT properties, such as spray-drying, moisture treatment, sintering, and use of sugar-based disintegrants.
Patent
Rapidly dissolving robust dosage form
TL;DR: The tablet is created from an active ingredient mixed into a matrix of a non-direct compression filler and a relatively high lubricant content, and it dissolves rapidly in the mouth of the patient with a minimum of grit as discussed by the authors.
Fast-Melting Tablets: Developments and Technologies
TL;DR: Fast-dispersing formulations, commonly called fast-melting tablets (FMTs), also offer advantages over other dosage forms such as effervescent tablets, extemporary suspensions, chewing gum, or chewable tablets, which are commonly used to enhance patient compliance.
Journal ArticleDOI
Fast dispersible ibuprofen tablets.
TL;DR: A direct compression method was used to prepare these two types of tablets containing coated ibuprofen as a high dosed model drug, and fast dispersible tablets with acceptable hardness and desirable taste could be prepared within the optimum region.
Patent
Sublingual buccal effervescent
Sathasivan Indiran Pather,Rajendra K. Khankari,Jonathan D. Eichman,Joseph R. Robinson,John Hontz +4 more
TL;DR: In this paper, a pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption in the oral cavities.
References
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Patent
Fast dissolving buccal tablet
TL;DR: A fast dissolving buccal tablet for administering a medicament includes the active ingredient, a lubricant and a water soluble sugar, such as sorbitol, combined such that the tablet dissolves in about one minute as mentioned in this paper.
Patent
Quick-liquifying, chewable tablet
TL;DR: In this article, a tablet has a harder outer shell which inhibits penetration of liquid into the interior of the tablet, and a softer interior which quickly liquifies when the tablet and shell are broken into pieces and contacted by the liquid.
Patent
Intrabuccally disintegrating preparation and production thereof
Katsuhiro Masaki,Kazutoshi Ban +1 more
TL;DR: A solid preparation soluble in the buccal cavity, which is composed of a sugar comprising lactose and/or manitol and 1-12 w/w%, based on the sugar, of agar and an active ingredient, has a density of 400-1,000 mg/ml and such a strength as to withstand the handling in the manufacture thereof as discussed by the authors.
Patent
Fast dissolving dosage forms
TL;DR: A pharmaceutical dosage form is provided which disintegrates rapidly in water having an open matrix network structure comprised of mannitol and a natural gum and which can be used particularly for oral administration to pediatric and geriatric patients as discussed by the authors.
Patent
Preparation of pharmaceutical and other matrix systems by solid-state dissolution
TL;DR: In this paper, a method for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the solidified matrix with a second solvent that is substantially miscible with the first solvent at a temperature lower than the solidification point of the first one, the matrix components being substantially insoluble in the second solvent.