Journal ArticleDOI
Orally fast disintegrating tablets: developments, technologies, taste-masking and clinical studies.
TLDR
This review describes in detail FDT technologies based on lyophilization, molding, sublimation, and compaction, as well as approaches to enhancing the FDT properties, such as spray-drying, moisture treatment, sintering, and use of sugar-based disintegrants.Abstract:
Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several FDT technologies. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail FDT technologies based on lyophilization, molding, sublimation, and compaction, as well as approaches to enhancing the FDT properties, such as spray-drying, moisture treatment, sintering, and use of sugar-based disintegrants. In addition, taste-masking technologies, experimental measurements of disintegration times, and clinical studies are also discussed.read more
Citations
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Journal ArticleDOI
3D printing in pharmaceutics: A new tool for designing customized drug delivery systems
Jonathan Goole,Karim Amighi +1 more
TL;DR: This paper aims to review the processes that can be used in pharmaceutics, including the parameters to be controlled, to give an overview on the pragmatic tools, which can beused for designing customized drug delivery systems using 3D printing.
Journal ArticleDOI
Binder jetting: A review of process, materials, and methods
Mohsen Ziaee,Nathan B. Crane +1 more
TL;DR: A broad review of technologies and approaches that have been applied in Binder Jet printing and points towards opportunities for future advancement is presented in this article, where a wide variety of materials including polymers, metals, and ceramics have been processed successfully with Binder jet.
Journal ArticleDOI
Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers.
Deng-Guang Yu,Xiaxia Shen,Christopher Branford-White,Kenneth White,Li-Min Zhu,S. W. Annie Bligh +5 more
TL;DR: Electrospun ultrafine fibers have the potential to be used as solid dispersions to improve the dissolution profiles of poorly water-soluble drugs or as oral fast disintegrating drug delivery systems.
Journal ArticleDOI
Orodispersible tablets: An overview
TL;DR: This review describes the various formulation aspects, disintegrants employed and technologies developed for ODTs, along with various excipients, evaluation tests, marketed formulations, and drugs explored in this field.
Journal ArticleDOI
Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin
TL;DR: Electrospun nanofibers prepared from electrospinning PVA/drug aqueous solutions possessed an ultrafine morphology with an average diameter in the range of 260-370 nm, indicating that drugs can be released in a burst manner.
References
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Journal ArticleDOI
Drug-delivery products and the Zydis fast-dissolving dosage form.
TL;DR: Many patients find it difficult to swallow tablets and hard gelatin capsules and do not take their medication as prescribed, but such problems can be resolved by means of the Zydis dosage form which does not require water to aid swallowing.
Journal ArticleDOI
Recent technological advances in oral drug delivery - a review.
TL;DR: This article provides a comprehensive review of oral fast-dispersing dosage forms, three-dimensional Printing (3DP) and electrostatic coating.
Journal ArticleDOI
Preparation and Evaluation of a Compressed Tablet Rapidly Disintegrating in the Oral Cavity
TL;DR: In order to make a compressed tablet which can rapidly disintegrate in the oral cavity, microcrystalline cellulose and low-substituted hydroxypropylcellulose were used as disintegrants, and ethenzamide and ascorbic acid were chosen as poorly and easily water soluble model drugs, respectively.
Journal Article
Fast-dissolving tablets
TL;DR: This artide describes existing fast-dissolving technologies and discusses several techniques used to formulate such tablets, namely tablet molding, freeze-drying, spray-Drying, sublimation, disintegrant addition, and the use of sugar-based excipients.
Patent
Rapidly dissolving robust dosage form
TL;DR: The tablet is created from an active ingredient mixed into a matrix of a non-direct compression filler and a relatively high lubricant content, and it dissolves rapidly in the mouth of the patient with a minimum of grit as discussed by the authors.