Journal ArticleDOI
Fatal enterovirus 71 encephalomyelitis
Lucy Chai See Lum,Kum Thong Wong,Sai Kit Lam,Kaw Bing Chua,Adrian Yu Teik Goh,W.L. Lim,B.B. Ong,George Paul,Sazaly AbuBakar,M. Lambert +9 more
TLDR
An etiologic link between EV-71 and brainstem encephalomyelitis is postulated as the cause of pulmonary edema and death in children with sudden cardiopulmonary collapse in 1997.About:
This article is published in The Journal of Pediatrics.The article was published on 1998-12-01. It has received 322 citations till now. The article focuses on the topics: Encephalomyelitis & Enterovirus 71.read more
Citations
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Journal ArticleDOI
An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group.
Monto Ho,Eng-Rin Chen,Kwo-Hsiung Hsu,Shiing-Jer Twu,Kow-Tong Chen,Su-Fen Tsai,Jen Ren Wang,Shin-Ru Shih +7 more
TL;DR: Although several enteroviruses were circulating in Taiwan during the 1998 epidemic, enterovirus 71 infection was associated with most of the serious clinical manifestations and with nearly all the deaths.
Journal ArticleDOI
Virology, epidemiology, pathogenesis, and control of enterovirus 71.
Tom Solomon,Tom Solomon,Penny Lewthwaite,David Perera,Mary Jane Cardosa,Peter McMinn,Mong How Ooi,Mong How Ooi +7 more
TL;DR: Enterovirus 71 is a major public health issue across the Asia-Pacific region and beyond, with new outbreaks occurring across Asia in regular cycles, and virus gene subgroups seem to differ in clinical epidemiological properties.
Journal ArticleDOI
An overview of the evolution of enterovirus 71 and its clinical and public health significance
Peter C. McMinn,Peter C. McMinn +1 more
TL;DR: Control of EV71 epidemics through high-level surveillance and public health intervention needs to be maintained and extended throughout the Asia-Pacific region if an effective live-attenuated vaccine is developed.
Journal ArticleDOI
Neurologic complications in children with enterovirus 71 infection.
TL;DR: In the 1998 enterovirus 71 epidemic in Taiwan, the chief neurologic complication was rhombencephalitis, which had a fatality rate of 14 percent and the most common initial symptoms were myoclonic jerks, and MRI usually showed evidence of brainstem involvement.
Journal ArticleDOI
Deaths of Children during an Outbreak of Hand, Foot, and Mouth Disease in Sarawak, Malaysia: Clinical and Pathological Characteristics of the Disease
L. G. Chan,Umesh D. Parashar,M. S. Lye,Flora Ong,Sherif R. Zaki,James Alexander,K. K. Ho,Linda L. Han,Mark A. Pallansch,Abu Bakar Suleiman,M. Jegathesan,Larry J. Anderson +11 more
TL;DR: Brain-stem specimens from 2 patients were available, and both specimens showed extensive neuronal degeneration, inflammation, and necrosis, suggesting that a central nervous system infection was responsible for the disease, with the cardiopulmonary dysfunction being neurogenic in origin.
References
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Journal ArticleDOI
An Apparently New Enterovirus Isolated from Patients with Disease of the Central Nervous System
TL;DR: The human origin of the virus strains was confirmed by the reisolation from the original clinical specimens and the demonstration of increases in neutralizing antibody in patients from whom virus was isolated, and cross-neutralization and immunodiffusion tests indicated that the virus was distinct from the currently recognized enteroviruses of man.
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Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria.
M. P. Chumakov,M. K. Voroshilova,L. Shindarov,I. K. Lavrova,L. A. Gracheva,Koroleva Ga,S. Vasilenko,I Brodvarova,M Nikolova,S Gyurova,M Gacheva,G Mitov,N Ninov,E Tsylka,I Robinson,Frolova Mp,Bashkirtsev Vn,L Martiyanova,V Rodin +18 more
TL;DR: Austrian strains of enterovirus 71 regularly caused paralysis in monkeys and morphological poliomyelitis-like lesions in their CNS, and paralysis and myositis with Zenker necrosis in newborn white mice, cotton rats, Syrian hamsters, and 3-week-old cotton rats.
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Virological diagnosis of enterovirus type 71 infections: Experiences gained during an epidemic of acute CNS diseases in Hungary in 1978
TL;DR: Investigation of 684 blood samples from 511 patients for E71-specific IgM antibodies showed this test to be the most reliable for the detection of current E71 infections, which made an aetiological diagnosis possible in 236 cases which otherwise would have remained undetermined.
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Enterovirus 71 Infections and Neurologic Disease—United States, 1977–1991
TL;DR: Enterovirus 71 has been endemic in the United States since at least 1977, was identified more frequently in 1987 than in other years, and continues to be an occasional cause of severe neurologic disease.
Journal ArticleDOI
Outbreaks of hand, foot, and mouth disease by enterovirus 71: high incidence of complication disorders of central nervous system.
TL;DR: The enterovirus 71 isolated in Japan had strong dermatotropic as well as neurotropic tendencies, however in cross-neutralisation tests, no difference in antigenicity from the prototype, BrCr strain, was recognised.