Outbreaks of hand, foot, and mouth disease by enterovirus 71: high incidence of complication disorders of central nervous system.
TLDR
The enterovirus 71 isolated in Japan had strong dermatotropic as well as neurotropic tendencies, however in cross-neutralisation tests, no difference in antigenicity from the prototype, BrCr strain, was recognised.Abstract:
In Japan we have had two outbreaks of hand, foot, and mouth disease associated with disorders of the central nervous system, one in 1973 and the other in 1978. The isolated virus in both outbreaks was enterovirus 71. Central nervous system disorders were present in 24% of patients in 1973 and in 8% of patients in 1978. These disorders were localised encephalitis with cerebellar signs as the main feature, aseptic meningitis, and polio-like paresis. The enterovirus 71 isolated in Japan had strong dermatotropic as well as neurotropic tendencies. However in cross-neutralisation tests, no difference in antigenicity from the prototype, BrCr strain, was recognised.read more
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An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group.
Monto Ho,Eng-Rin Chen,Kwo-Hsiung Hsu,Shiing-Jer Twu,Kow-Tong Chen,Su-Fen Tsai,Jen Ren Wang,Shin-Ru Shih +7 more
TL;DR: Although several enteroviruses were circulating in Taiwan during the 1998 epidemic, enterovirus 71 infection was associated with most of the serious clinical manifestations and with nearly all the deaths.
Journal ArticleDOI
Virology, epidemiology, pathogenesis, and control of enterovirus 71.
Tom Solomon,Tom Solomon,Penny Lewthwaite,David Perera,Mary Jane Cardosa,Peter McMinn,Mong How Ooi,Mong How Ooi +7 more
TL;DR: Enterovirus 71 is a major public health issue across the Asia-Pacific region and beyond, with new outbreaks occurring across Asia in regular cycles, and virus gene subgroups seem to differ in clinical epidemiological properties.
Journal ArticleDOI
Clinical features, diagnosis, and management of enterovirus 71
Mong How Ooi,Mong How Ooi,See Chang Wong,Penny Lewthwaite,Mary Jane Cardosa,Tom Solomon,Tom Solomon +6 more
TL;DR: Clinical predictors of severe disease include high temperature and lethargy, and lumbar puncture might reveal pleocytosis, and intravenous immunoglobulin seems to be beneficial in severe disease, perhaps through non-specific anti-inflammatory mechanisms, but has not been tested in any formal trials.
Journal ArticleDOI
An overview of the evolution of enterovirus 71 and its clinical and public health significance
Peter C. McMinn,Peter C. McMinn +1 more
TL;DR: Control of EV71 epidemics through high-level surveillance and public health intervention needs to be maintained and extended throughout the Asia-Pacific region if an effective live-attenuated vaccine is developed.
Journal ArticleDOI
Neurologic complications in children with enterovirus 71 infection.
TL;DR: In the 1998 enterovirus 71 epidemic in Taiwan, the chief neurologic complication was rhombencephalitis, which had a fatality rate of 14 percent and the most common initial symptoms were myoclonic jerks, and MRI usually showed evidence of brainstem involvement.
References
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An Apparently New Enterovirus Isolated from Patients with Disease of the Central Nervous System
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Journal Article
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New enterovirus type associated with epidemic of aseptic meningitis and/or hand, foot, and mouth disease
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Epidemic of Hand, Foot and Mouth Disease Associated with Enterovirus 71 Infection
TL;DR: Viruses isolated from patients with hand, foot and mouth disease in widespread outbreaks in Japan in 1973 were identified as enterovirus 71, and cases with aseptic meningitis were observed concurrently.
Journal Article
Enterovirus type 71 infection in Melbourne.
TL;DR: Most of the epidemic strains required sodium deoxycholate treatment before neutralization could be demonstrated, and could not be identified with antisera prepared against the prototype polio, coxsackie, and echo viruses.