Open AccessJournal Article
Flow injection spectrophotometric system for N-acetyl-L-cysteine determination in pharmaceuticals
Ana Luiza De Toledo Fornazari,Willian Toito Suarez,Heberth Juliano Vieira,Orlando Fatibello-Filho +3 more
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TLDR
In this paper, a flow injection system with spectrophotometric detection was proposed for determining N-acetyl-L-cysteine in pharmaceutical formulations, and the linearity of the calibration curve for Nacetyl L-Cysteine ranged from 3.5×10-6 to 4.3×10 -4 M.Abstract:
A flow injection system with spectrophotometric detection is proposed for determining N-acetyl-L-cysteine in pharmaceutical formulations. In this system, N-acetyl-L-cysteine was oxidized by Fe(III) and the Fe(II) producedis spectrophotometrically monitored as Fe(II)-1,10-phenantroline complex at 510 nm. Under the optimum analytical conditions, the linearity of the calibration curve for N-acetyl-L-cysteine ranged from 3.5×10 - 6 to 4.3×10 - 4 M. The detection limit of 6.3×10 - 7 M and recoveries between 98.5 to 110% were obtained.read more
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Journal ArticleDOI
Simultaneous determination of N-acetylcysteine and acetaminophen by voltammetric method using N-(3,4-dihydroxyphenethyl)-3,5-dinitrobenzamide modified multiwall carbon nanotubes paste electrode
TL;DR: In this paper, a dopamine-derivative, i.e., N-(3,4-dihydroxyphenethyl)-3,5-dinitrobenzamide (N-DHPB), was synthesized and its application was investigated for the simultaneous determination of N-acetylcysteine (NAC) and acetaminophen (AC) using modified multiwall carbon nanotubes paste electrode.
Journal ArticleDOI
Review of recent applications of flow injection spectrophotometry to pharmaceutical analysis.
TL;DR: The principles, figures of merit and "chemistry" of the presented methods can be of interest to bio-analytical and clinical chemists as well for the analysis of biological samples, to environmental analysts that study the up-to-date demand of the determination of the fate of pharmaceuticals in the environment and even to toxicologists and forensic scientists.
Journal ArticleDOI
Voltammetric determination of N-acetylcysteine using a carbon paste electrode modified with copper(II) hexacyanoferrate(III)
TL;DR: In this article, the preparation and electrochemical characterization of a carbon paste electrode modified with copper(II) hexacyanoferrate(III) (CuHCF) as well as its behavior as electrocatalyst toward the oxidation of N -acetylcysteine were investigated.
Journal ArticleDOI
Differential pulse voltammetric determination of N-acetylcysteine by the electrocatalytic oxidation at the surface of carbon nanotube-paste electrode modified with cobalt salophen complexes
TL;DR: In this paper, a carbon nanotube-paste electrode was modified with salophen complexes of cobalt(III) perchlorate, with various substituents on the salophen ligand, as well as their electrocatalytic activity toward the oxidation of N-acetylcysteine (NAC).
Journal ArticleDOI
A glassy carbon electrode modified with carbon quantum dots and polyalizarin yellow R dyes for enhanced electrocatalytic oxidation and nanomolar detection of l-cysteine
TL;DR: In this paper, a novel electrochemical sensor for the detection of l -cysteine was proposed based on immobilizing poly (alizarin yellow R)/carbon quantum dots film on glassy carbon electrode.
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Book
Flow Injection Analysis Of Pharmaceuticals
TL;DR: A critical review of published papers as discussed by the authors presents theoretical and fundamental aspects of FIA-pharmaceutical analyses, divided the material into chapters based on measurement technique or type of detector, each chapter provides