D
Dimitrios Tsikas
Researcher at Hannover Medical School
Publications - 420
Citations - 14817
Dimitrios Tsikas is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Asymmetric dimethylarginine & Nitrite. The author has an hindex of 54, co-authored 390 publications receiving 13072 citations. Previous affiliations of Dimitrios Tsikas include University of Groningen.
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Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges
TL;DR: In this paper, the authors reviewed reported analytical methods and their principles for the quantitative measurement of MDA, HNE and 15(S)-8-iso-PGF2α in biological samples including plasma and urine, and critically discusses their biological and biomedical outcome which is rarely crystal clear and free of artefacts.
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Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the L-arginine/nitric oxide area of research.
TL;DR: The present article gives an overview of the currently available assays of nitrite and nitrate in biological fluids based on the Griess reaction, the most frequently used analytical approach to quantitate the major metabolites of NO, i.e. nitriteand nitrate, in a variety of biological fluids, notably blood and urine.
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Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia
Makrina D. Savvidou,Aroon D. Hingorani,Dimitrios Tsikas,Jürgen C. Frölich,Patrick Vallance,Kypros H. Nicolaides +5 more
TL;DR: Maternal endothelial function is impaired in women who eventually develop pre-eclampsia and it occurs before the development of the clinical syndrome, which is associated with endothelial dysfunction in some women.
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LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases.
Rainer H. Böger,Karsten Sydow,Jürgen Borlak,Thomas Thum,Henrike Lenzen,Bibiana Schubert,Dimitrios Tsikas,Stefanie M. Bode-Böger +7 more
TL;DR: The data suggest that the production of ADMA by human endothelial cells is regulated by S-adenosylmethionine-dependent methyltransferases, which may be due in part to the enhanced gene expression of PRMTs.
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Cardiovascular Effects of Systemic Nitric Oxide Synthase Inhibition With Asymmetrical Dimethylarginine in Humans
Jan T. Kielstein,Burcu Impraim,Solveig Simmel,Stefanie M. Bode-Böger,Dimitrios Tsikas,Jürgen C. Frölich,Marius M. Hoeper,Hermann Haller,Danilo Fliser +8 more
TL;DR: Systemic ADMA infusion is responsible for a short-term, modest decrease in cardiac output with comparable decrease in effective renal plasma flow while increasing systemic vascular resistance and blood pressure in a dose-related manner.