Gastric hyposection produced in rats by long-term oral administration of glycopyrrolate.

TLDR: Long-term administration of an anticholinergic drug in drinking water appears to be an easy experimental method of induction of gastric secretory hypofunction in rats.

Abstract: An anticholinergic drug, 1-methyl-3-pyrrolidyl-2-phenylcyclopentaneglycolate methobromide (glycopyrrolate) dissolved in drinking water, was given to the rats. The treatment lasted for 5 months. A secretion study was then performed in gastric fistula-bearing animals, infused for 24 h with normal saline or histamine. A significant decrease of the secretory function of parietal and zymogenic cells was found in treated rats, as compared with untreated control animals. Long-term administration of an anticholinergic drug in drinking water appears to be an easy experimental method of induction of gastric secretory hypofunction in rats.