Journal ArticleDOI
Giant histiocytes after cyclophosphamide.
TLDR
Nel midollo osseo di topi intossicati con dosi elevate di ciclofosfamide compaiono elementi giganti, che, per la capacità fagocitaria di cui sono dotati, appaioni appartenere al sistema istiocitario (istiociti giganti).Abstract:
Nel midollo osseo di topi intossicati con dosi elevate di ciclofosfamide compaiono elementi giganti, che, per la capacita fagocitaria di cui sono dotati, appaiono appartenere al sistema istiocitario (istiociti giganti).read more
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Cell survival in B16 melanoma after treatment with combinations of cytotoxic agents: lack of potentiation.
TL;DR: In the B16 melanoma there was no evidence of schedule-dependent cell killing with either of these combinations of vincristine + cyclophosphamide and 5-fluorouracil + gamma-rays, and for all sequences studied, the fraction of surviving cells per tumour was slightly greater than the predicted additive response calculated from single-drug controls.
Journal ArticleDOI
Secretory cells in the medulla of the bursal follicle: the small lymphocyte-like cells are precursors of the secretory cells.
Imre Olah,Bruce Glick +1 more
TL;DR: It is suggested that the Sll belong to the null cell population of the bursa of Fabricius are blood-borne cells with proliferative capabilities and are precursors of the secretory cells.
Journal ArticleDOI
Further studies on the neurochemical specificity of 6-hydroxydopamine as compared to radiofrequency lesions.
TL;DR: A novel method of determining the degree of neurochemical specificity which can be achieved with 6-OHDA is introduced and it is revealed that it is several magnitudes more neurochemically specific than RF lesions.
Journal Article
Growth response of B16 melanoma to in vivo treatment with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) at the initial stage after tumor transplantation.
TL;DR: The results suggest that a 7-day growth delay of drug-treated tumors is characterized not only by a reduced number of intact tumor cells but also by a severely suppressed proliferative capacity.
Journal ArticleDOI
The effect of cyclophosphamide, methotrexate and x‐irradiation on the ultrastructure and endocytic capacity of murine peritoneal macrophages
TL;DR: Treatment of mice with methotrexate for 5 days, although affecting the cells morphologically in that they were larger than normal cells and had many vacuoles did not appear to have any effect on either phagocytosis or pinocytotic.