Journal ArticleDOI
Grand RoundHepatic brucelloma
Letizia Barutta,Domenico Ferrigno,Remo Melchio,Valentina Borretta,Christian Bracco,Chiara Brignone,Alessia Giraudo,Cristina Serraino,Enrico Baralis,Maurizio Grosso,Luigi Fenoglio +10 more
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TLDR
A case of hepatic abscess caused by Brucella melitensis (or hepatic brucelloma) diagnosed in a 59-year-old man 33 years after an episode of acute brucellosis that had completely resolved is presented.Abstract:
We present a case of hepatic abscess caused by Brucella melitensis (or hepatic brucelloma) diagnosed in a 59-year-old man 33 years after an episode of acute brucellosis that had completely resolved. Recovery from symptoms and a decrease in lesion size seen on radiological assessment were achieved through prolonged combined antibiotic therapy, without the need for surgery. Hepatic brucelloma is a rare complication of brucellosis, which is the most common zoonosis globally, mainly occurring in specific endemic areas and causing a range of clinical manifestations. In this Grand Round, we review the clinical manifestations, diagnostic approach (through laboratory, radiology, and histology findings), differential diagnosis, treatment, and prognosis of hepatic brucelloma.read more
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Medical Microbiology, 4th Edition [Book Review]
TL;DR: The 4th edition of Medical Microbiology, 4th Edition, edited by Patrick R Murray, Ken S Rosenthal, George Kobayashi and Michael A Pfaller, Mosby, 826 pages, hardcover, ISBN: 0323012132, A$109.00.
Journal ArticleDOI
Human Monkeypox in Sierra Leone after 44-Year Absence of Reported Cases.
Mary G. Reynolds,Nadia Wauquier,Yu Li,Panayampalli Subbian Satheshkumar,Lansana Kanneh,Benjamin Monroe,Jacob Maikere,Gbessay Saffa,Jean-Paul Gonzalez,Joseph N. Fair,Darin S. Carroll,Amara Jambai,Foday Dafae,Sheik Humarr Khan,Lina M. Moses +14 more
TL;DR: The reemergence of human monkeypox in Sierra Leone following a 44-year absence of reported disease suggests a need for renewed vigilance and awareness of the disease and its manifestations.
Journal ArticleDOI
Patterns of Hepatosplenic Brucella Abscesses on Cross-Sectional Imaging: A Review of Clinical and Imaging Features.
Tom Heller,Sabine Bélard,Claudia Wallrauch,Edoardo Carretto,Raffaella Lissandrin,Carlo Filice,Enrico Brunetti +6 more
TL;DR: Clinicians should be aware of hepatosplenic abscesses due to Brucella infections and the proactive use of cross-sectional imaging, particularly US, should be encouraged in endemic regions.
Journal Article
Hepatic granulomas associated with brucellosis
Ayse Albayrak,Fatih Albayrak +1 more
TL;DR: The Brucella organism’s predilection for organs rich in reticuloendothelial cells and its intracellular location are responsible for the chronicity of the disease, which can last for months or even years.
Journal ArticleDOI
When Bacterial Culture Fails, Metagenomics Can Help: A Case of Chronic Hepatic Brucelloma Assessed by Next-Generation Sequencing.
Vladimir Lazarevic,Nadia Gaïa,Myriam Girard,Stefano Leo,Abdessalam Cherkaoui,Gesuele Renzi,Stéphane Emonet,Sharon Jamme,Etienne Ruppé,Sandrine Elisabeth Vijgen,Laura Rubbia-Brandt,Christian Toso,Jacques Schrenzel +12 more
TL;DR: DNA extracted from a necrotic hepatic lesion from a patient with suspected chronic hepatic brucelloma but negative culture results suggests that whole-metagenome shotgun sequencing may be used together with other tests to strengthen the diagnosis of hepatic Brucelloma.
References
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Journal ArticleDOI
The new global map of human brucellosis
Georgios Pappas,Photini Papadimitriou,Nikolaos Akritidis,Leonidas Christou,Epameinondas V. Tsianos +4 more
TL;DR: The epidemiology of human brucellosis has drastically changed over the past decade because of various sanitary, socioeconomic, and political reasons, together with the evolution of international travel.
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Brucellosis: an overview.
TL;DR: No satisfactory vaccines against human brucellosis are available, although attenuated purE mutants appear promising, andPolymerase chain reaction and gene probe development may provide more effective typing methods.
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Complications associated with Brucella melitensis infection: a study of 530 cases.
Juan de Dios Colmenero,J.M. Reguera,F Martos,Sánchez-De-Mora D,Miguel Delgado,Causse M,Martín-Farfán A,C Juarez +7 more
TL;DR: The incidence and clinical features of the focal forms of the disease are described, analyzing some of the possible factors associated with their appearance, and the risk of an unfavorable evolution was significantly greater in patients with focal forms.
Journal ArticleDOI
Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature
Turan Buzgan,Mustafa Kasim Karahocagil,Hasan Irmak,Ali İrfan Baran,Hasan Karsen,Ömer Evirgen,Hayrettin Akdeniz +6 more
TL;DR: Regimens including doxycycline and streptomycin with or without rifampin appeared more effective than other regimens in osteoarticular involvement and there is no recommended treatment protocol for complicated brucellosis.
Journal ArticleDOI
Clinical manifestations of human brucellosis: a systematic review and meta-analysis.
Anna S. Dean,Lisa Crump,Lisa Crump,Helena Greter,Helena Greter,Jan Hattendorf,Jan Hattendorf,Esther Schelling,Esther Schelling,Jakob Zinsstag,Jakob Zinsstag +10 more
TL;DR: This systematic review adds to the understanding of the global burden of brucellosis, one of the most common zoonoses worldwide, and the severe, debilitating, and chronic impact of bru cellosis is highlighted.