Journal ArticleDOI
Haemodynamic Effects of the Multiple Action Antihypertensive Drug Urapidil
Reads0
Chats0
TLDR
The evidence that the antihypertensive effect of urapidil is due to a systemic vasodilatation with no change in cardiac output, no tachycardia and no under-perfusion of vital organs is reviewed.Abstract:
This paper reviews the evidence that the antihypertensive effect of urapidil is due to a systemic vasodilatation with no change in cardiac output, no tachycardia and no under-perfusion of vital organs. Urapidil does not impair the cardiovascular control exerted by arterial baroreceptors and cardiopulmonary receptors. This is probably the reason why no orthostatic hypotension and derangement in blood pressure homeostasis follows its administration.read more
Citations
More filters
Journal ArticleDOI
Effect of S-adenosyl-L-methionine on rat brain oxidative stress damage in a combined model of permanent focal ischemia and global ischemia-reperfusion.
M.A. Villalobos,J.P. De La Cruz,M.A. Cuerda,P. Ortiz,J.M. Smith-Agreda,F. Sánchez de la Cuesta +5 more
TL;DR: It is concluded that SAM reduces oxidative damage in the rat brain in an experimental model of ischemia-reperfusion.
Book ChapterDOI
Fall 3 – Pankreasoperation
TL;DR: In this paper, Dr. Constantin argert sich zunachst uber diese Operation im Bereitschaftsdienst, aber als er den Patienten sieht, andert er seine Meinung.
Renal hemodynamic and neurohumoral responses to urapidil in hypertensive man
TL;DR: Urapidil, given intravenously, has an immediate blood pressure lowering effect associated with a fall in renal vascular tone and an increase in renal perfusion, and both the sympathetic system and the renin-angiotensin system are stimulated, although the latter only to a mild degree.
References
More filters
OtherDOI
Arterial Baroreflexes in Humans
Giuseppe Mancia,Allyn L. Mark +1 more
TL;DR: The sections in this article are: Carotid Sinus Massage, Arterial Baroreceptor Control of Heart Rate, and Modification of Arteria Baroreflexes by Drugs.
OtherDOI
Cardiopulmonary Baroreflexes in Humans
Allyn L. Mark,Giuseppe Mancia +1 more
TL;DR: The sections in this article are: Techniques, Mechanisms of Bradycardia and Hypotension With Inferoposterior Infarction, Pathological States, and Interaction of Cardiopulmonary, Carotid, and Somatic Reflexes.
Journal ArticleDOI
Cardiopulmonary receptor modulation of plasma renin activity in normotensive and hypertensive subjects
Guido Grassi,Cristina Giannattasio,A. Saino,E Sabadini,A Capozi,Lorena Sampieri,Cesare Cuspidi,Giuseppe Mancia +7 more
TL;DR: Observations indicate that cardiopulmonary receptors modulate plasma renin activity in humans, and this control in hypertension is unclear.
Journal ArticleDOI
Renal haemodynamic and neurohumoral responses to urapidil in hypertensive man.
TL;DR: In this article, the acute effects of urapidil on renal vascular tone and on the pressor system were evaluated in 8 patients with uncomplicated essential hypertension with a randomized placebo-controlled crossover study.
Journal ArticleDOI
Basic pharmacology of alpha-adrenoceptor antagonists and hybrid drugs.
TL;DR: Urapidil's obvious central hypotensive activity, which is caused by an unusual, so far unknown mechanism, is an interesting feature, which may contribute to the absence of reflex tachycardia.