J
J. D. Spence
Researcher at University of Western Ontario
Publications - 85
Citations - 10156
J. D. Spence is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Blood pressure & Stroke. The author has an hindex of 39, co-authored 85 publications receiving 9571 citations. Previous affiliations of J. D. Spence include London Health Sciences Centre & Robarts Research Institute.
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Journal ArticleDOI
Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators.
H.J.M. Barnett,D W Taylor,Michael Eliasziw,Allan J. Fox,Gary G. Ferguson,Richard Haynes,R N Rankin,G. P. Clagett,Vladimir Hachinski,David L. Sackett,Kevin E. Thorpe,Heather Meldrum,J. D. Spence +12 more
TL;DR: Benefit of carotid endarterectomy was greatest among men, patients with recent stroke as the qualifying event, and patients with hemispheric symptoms, and decisions about treatment for patients in this category must take into account recognized risk factors.
Journal ArticleDOI
Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition
TL;DR: The clinical importance of any drug interaction depends on factors that are drug-, patient- and administration-related and is likely to be dependent on interindividual differences in CYP3A4 tissue content, pre-existing medical conditions and, possibly, age.
Journal ArticleDOI
Pioglitazone after Ischemic Stroke or Transient Ischemic Attack
Walter N. Kernan,Catherine M. Viscoli,Karen L. Furie,Lawrence H. Young,Silvio E. Inzucchi,Mark Gorman,Peter Guarino,Peter Guarino,Anne M. Lovejoy,Peter Peduzzi,Peter Peduzzi,Robin Conwit,Lawrence M. Brass,Gregory G. Schwartz,Harold P. Adams,L. Berger,Antonio Carolei,Wayne M. Clark,Bruce M. Coull,Gary A. Ford,Dawn Kleindorfer,J. R. O'Leary,Mark W Parsons,Peter A. Ringleb,Souvik Sen,J. D. Spence,David Tanne,David Z. Wang,T. R. Winder +28 more
TL;DR: In this trial involving patients without diabetes who had insulin resistance along with a recent history of ischemic stroke or TIA, the risk of stroke or myocardial infarction was lower among patients who received pioglitazone than among those who received placebo.
Journal ArticleDOI
Interaction of citrus juices with felodipine and nifedipine.
TL;DR: Six men with borderline hypertension took felodipine 5 mg with water, grapefruit juice, or orange juice; the bioavailability with grapefruit Juice was lower, diastolic blood pressure lower, and heart rate higher with Grapefruit juice than with water.
Journal ArticleDOI
Carotid endarterectomy—An evidence-based review Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
Seemant Chaturvedi,Askiel Bruno,Thomas E. Feasby,Robert G. Holloway,Oscar R. Benavente,Stanley N. Cohen,Robert Côté,David C. Hess,Jeffrey L. Saver,J. D. Spence,B. Stern,Janet Wilterdink +11 more
TL;DR: Evidence supports carotid endarterectomy for severe (70 to 99%) symptomatic stenosis and moderately useful for symptomatic patients with 50 to 69% stenosis (Level A).