Journal ArticleDOI
Highly enantioselective HPLC separations using the covalently bonded macrocyclic antibiotic, ristocetin A, chiral stationary phase
TLDR
The ristocetin A CSP appeared to be complimentary to other glycopeptide CSPs (i.e., vancomycin and teicoplanin).About:
This article is published in Chirality.The article was published on 1998-01-01. It has received 155 citations till now.read more
Citations
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Journal ArticleDOI
Separation of enantiomers: needs, challenges, perspectives☆
TL;DR: The present implications of their chiral nature and necessity of separating enantiomers are summarised in this article and a brief overview of the actual approaches to perform enantioseparations at analytical and preparative scale is given.
Journal ArticleDOI
Chiral recognition by enantioselective liquid chromatography: Mechanisms and modern chiral stationary phases
TL;DR: This tutorial review is mainly focused on mechanisms of chiral recognition and enantiomer distinction of popular chiral selectors and corresponding chiral stationary phases and attempts to provide the reader with vivid images of molecular recognition mechanisms of selected chiral selector-selectand pairs on basis of solid-state X-ray crystal structures and simulated computer models.
Journal ArticleDOI
Chiral separations using the macrocyclic antibiotics: a review
Timothy J. Ward,Alton B. Farris +1 more
TL;DR: The macrocyclic antibiotics have recently gained popularity as chiral selectors in CE, HPLC and TLC and are complementary to one another, where if a partial enantioresolution is obtained with one glycopeptide, there is a high probability that a baseline or better separation can be obtained with another.
Journal ArticleDOI
Recent applications in chiral high performance liquid chromatography: a review.
TL;DR: The most important and broadly used chiral stationary phases (CSPs) for high performance liquid chromatography (HPLC) are reviewed and emphasis is given to new, emerging CSPs that seem to possess all requisites to be considered potentially successful chiral separation media in the next future.
Journal ArticleDOI
Chiral separation by chromatographic and electromigration techniques. A Review
Gerald Gübitz,Martin G. Schmid +1 more
TL;DR: This review gives a survey of different chiral separation principles and their use in high‐performance liquid chromatography (HPLC), gas chromatography, supercritical fluid Chromatography (SFC), thin‐layer chromatography(TLC), capillary electrophoresis (CE) and capillary electrochromatography (CEC) highlighting new developments and innovative techniques.
References
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Journal ArticleDOI
Macrocyclic Antibiotics as a New Class of Chiral Selectors for Liquid Chromatography
TL;DR: In this article, three representative macrocyctic compounds were covalently linked to silica gel and evaluated by HPLC for their ability to resolve racemic mixtures as well as for their stability and loadability.
Journal ArticleDOI
A covalently bonded teicoplanin chiral stationary phase for HPLC enantioseparations
TL;DR: It appears that teicoplanin is a widely applicable, highly effective chiral selector for HPLC enantioseparations.
Journal ArticleDOI
Facile liquid chromatographic enantioresolution of native amino acids and peptides using a teicoplanin chiral stationary phase
TL;DR: The glycopeptide antibiotic teicoplanin is shown to be a highly effective stationary phase chiral selector for the resolution of underivatized amino-acid and imino-acid enantiomers and the enantioselective separation mechanism is examined using both molecular modeling and retention data.
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Evaluation of the macrocyclic antibiotic vancomycin as a chiral selector for capillary electrophoresis
TL;DR: The physiochemical properties of vancomycin, including its stability in solution, are discussed as they pertain to capillary electrophoresis and Optimization and the effect of different experimental parameters on the enantioselective separations are discussed.
Journal ArticleDOI
Modifications of the acyl-d-alanyl-d-alanine terminus affecting complex-formation with vancomycin
Manuel Nieto,H. R. Perkins +1 more
TL;DR: Results throw some light on the specificity of the uptake of vancomycin by living bacteria.