Journal ArticleDOI
Human Growth Hormone Levels in Cerebrospinal Fluid
TLDR
The invariably high levels of HGH in CSF in acromegaly, particularly associated with suprasellar extension of the pituitary mass, indicate that a large peptide hormone can cross the blood-CSF barrier.Abstract:
Nine patients with uncomplicated acromegaly showed the cerebrospinal fluid (CSF) human growth hormone (HGH) to be 0.49±0.11 ng/ml (mean±sem) as compared to 8 control subjects whose values were extremely low (<0.09±0.01 ng/ml), with the majority below the sensitivity limit of the assay. Three other patients with suprasellar extension of the pituitary mass showed a 140- to 800-fold greater value of HGH in CSF as compared with the uncomplicated group. The invariably high levels of HGH in CSF in acromegaly, particularly associated with suprasellar extension of the pituitary mass, indicate that a large peptide hormone can cross the blood-CSF barrier. This measurement appears to have potential usefulness in the clinical evaluation of acromegalic patients.read more
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Journal ArticleDOI
Neuroendocrine Control of Growth Hormone Secretion
TL;DR: The secretion of growth hormone is regulated through a complex neuroendocrine control system, especially by the functional interplay of two hypothalamic hypophysiotropic hormones, GH-releasing hormone (GHRH) and somatostatin (SS), exerting stimulatory and inhibitory influences, respectively, on the somatotrope.
Journal ArticleDOI
The origin, distribution and synaptic relationships of substance P axons in rat spinal cord.
Robert P. Barber,James E. Vaughn,J. Randall Slemmon,Paul M. Salvaterra,Eugene Roberts,Susan E. Leeman +5 more
TL;DR: Substance P positive (SP+) immunoperoxidase reaction product has been localized in light and electron microscopic preparations of rat lumbar spinal cord using an immunocytochemical method and displayed densely‐stained varicosities and terminal puncta.
Journal ArticleDOI
Neuroendocrine control of growth hormone secretion.
TL;DR: Better understanding of the function of GHRH, SS, and their receptors and, hence, of neural regulation of GH secretion in health and disease has been achieved with the discovery of a new class of fairly specific, orally active, small peptides and their congeners, the GH-releasing peptides, acting on specific, ubiquitous seven-transmembrane domain receptors, whose natural ligands are not yet known.
Journal ArticleDOI
Cerebrospinal fluid and plasma free cortisol concentrations in depression.
TL;DR: A significant reduction of CSF cortisol levels was observed following treatment and recovery, and similar results were found in patient subgroups studied in Australia and in the United States.