Journal ArticleDOI
Hypoperfusion of the visual pathway in parkinsonian patients with visual hallucinations.
Hideaki Matsui,Kazuto Nishinaka,Masaya Oda,Narihiro Hara,Kenichi Komatsu,Tamotsu Kubori,Fukashi Udaka +6 more
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TLDR
Investigation of perfusion changes in parkinsonian patients with visual hallucinations using single photon emission computed tomography imaging suggested that hypoperfusion of the visual pathway was closely related to visual hallucinations in Parkinson's disease.Abstract:
Little is known about the developing mechanisms of visual hallucinations in Parkinson's disease. This study aimed to investigate perfusion changes in parkinsonian patients with visual hallucinations using n-isopropyl-p-[123I]iodoamphetamine ([123I]IMP) single photon emission computed tomography imaging. A total of 70 consecutive patients, including 31 patients with visual hallucinations, and 39 patients without hallucinations, participated in this study. Patients with severe cognitive impairment (Mini-Mental State Examination score < 20), nonvisual hallucinations, or confusion were excluded. We compared brain perfusion changes between the two groups. We found that hallucinatory patients had significant perfusion reductions in the bilateral inferior parietal lobule, inferior temporal gyrus, precuneus gyrus, and occipital cortex compared to nonhallucinatory patients. These results suggested that hypoperfusion of the visual pathway was closely related to visual hallucinations in Parkinson's disease. © 2006 Movement Disorder Societyread more
Citations
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Journal ArticleDOI
Parkinson's disease dementia: a neural networks perspective
TL;DR: It is argued that Parkinson’s disease dementia reflects dysfunction in seven distinct brain networks, with implications for therapeutic approaches.
Journal ArticleDOI
Impaired visual processing preceding image recognition in Parkinson's disease patients with visual hallucinations
Anne Marthe Meppelink,Anne Marthe Meppelink,Bauke M. de Jong,Bauke M. de Jong,Remco J. Renken,Klaus L. Leenders,Klaus L. Leenders,Frans W. Cornelissen,Frans W. Cornelissen,Teus van Laar +9 more
TL;DR: The association between increased vulnerability for visual hallucinations in Parkinson's disease and impaired visual object processing in occipital and temporal extrastriate visual cortices supported the hypothesis of impaired bottom-up visual processing in PDwithVHs.
Journal ArticleDOI
Visual symptoms in Parkinson's disease and Parkinson's disease dementia.
TL;DR: The results demonstrate that different “hallucinatory” experiences in PD do not necessarily share common disease predictors and may, therefore, be driven by different pathophysiological mechanisms, and have important implications for future studies of visual symptoms and cognitive decline in PD and PD dementia.
Journal ArticleDOI
Visuoperceptive region atrophy independent of cognitive status in patients with Parkinson’s disease with hallucinations
Jennifer G. Goldman,Glenn T. Stebbins,Vy Dinh,Bryan Bernard,Doug Merkitch,Leyla deToledo-Morrell,Christopher G. Goetz +6 more
TL;DR: The findings suggest that when hallucinators and non-hallucinators are similar in their cognitive performance, the neural networks involving visuoperceptual pathways, rather than the mesial temporal lobe regions, distinctively contribute to the pathophysiology of visual hallucinations and may explain their predominantly visual nature in Parkinson's disease.
Journal ArticleDOI
Differential progression of brain atrophy in Parkinson's disease with and without visual hallucinations
Naroa Ibarretxe-Bilbao,Blanca Ramirez-Ruiz,Carme Junqué,María José Martí,Francesc Valldeoriola,Núria Bargalló,Silvia Juanes,Eduardo Tolosa +7 more
TL;DR: The presence of VH in PD determines a different cognitive outcome and a different pattern of progressive brain atrophy, and significant correlations between the changes in several cognitive functions and grey-matter loss over time in PD patients with VH are found.
References
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Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
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A Diagnostic Approach in Alzheimer's Disease Using Three-Dimensional Stereotactic Surface Projections of Fluorine-18-FDG PET
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Journal ArticleDOI
Hallucinations in Parkinson's disease: prevalence, phenomenology and risk factors.
TL;DR: In this paper, the authors determined the phenomenology, prevalence and risk factors of hallucinations in Parkinson's disease and found that one-quarter of patients with Parkinson's have hallucinations, mainly of a visual nature.
Journal ArticleDOI
Cognitive status correlates with neuropathologic stage in Parkinson disease
TL;DR: The decrease in median Mini-Mental State Examination scores between PD stages 3 to 6 indicates that the risk of developing dementia increases with disease progression, and in some individuals, cognitive decline can develop in the presence of mild Parkinson disease–related cortical pathology and, conversely, widespread cortical lesions do not necessarily lead to cognitive decline.
Journal ArticleDOI
Complex visual hallucinations. Clinical and neurobiological insights.
M Manford,F Andermann +1 more
TL;DR: It is suggested that perturbation of a distributed matrix may explain the production of similar, complex mental phenomena by relatively blunt insults at disparate sites.