Journal ArticleDOI
Impairment of conditioned active avoidance in adult rats given corticosterone in infancy
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TLDR
Intensive corticosterone treatment given to rats during the 1st postnatal week irreversibly decreases DNA accumulation in the cerebrum and cerebellum and after such hypercorticism in infancy rats were tested as adults in 2 conditioned active avoidance tasks and were impaired in the acquisition of 2-way active avoidance.Abstract:
Intensive corticosterone treatment given to rats during the 1st postnatal week irreversibly decreases DNA accumulation in the cerebrum and cerebellum. After such hypercorticism in infancy rats were tested as adults in 2 conditioned active avoidance tasks. In comparison with litter-mate controls, the treated rats were impaired in the acquisition of 2-way active avoidance but not in the acquisition of 1-way active avoidance. These data are consistent with other observations suggesting a hyperresponsiveness or hyperemotionality following corticosterone treatment in infancy.read more
Citations
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Maturation of the adrenocortical stress response: Neuroendocrine control mechanisms and the stress hyporesponsive period
TL;DR: This work has attempted to explain adrenocortical activity during this period in terms of the unique pattern of glucocorticoid-receptor concentrations that exist in the brain and pituitary of the neonatal rat, which ensures the low, stable corticoid levels that appear to be optimal for neuronal development in glucocortex-sensitive brain regions.
Journal ArticleDOI
Developmental neurobiology of childhood stress and trauma
Martin H. Teicher,Susan L. Andersen,Susan L. Andersen,Ann Polcari,Carl M. Anderson,Carl M. Anderson,Carryl P. Navalta,Carryl P. Navalta +7 more
TL;DR: These alterations provide the neurobiological framework through which early abuse increases the risk of developing post-traumatic stress disorder (PTSD), depression, symptoms of attention-deficit/hyperactivity, borderline personality disorder, dissociative identity disorder, and substance abuse.
Journal ArticleDOI
Effects of prenatal stress on vulnerability to stress in prepubertal and adult rats
TL;DR: It is suggested that random prenatal noise and light stress may cause impairment of development of hippocampal function which lasts into adulthood, manifested as an increase in vulnerability and a decrease in habituation to stressful stimuli.
Journal ArticleDOI
Glucocorticoids: exemplars of multi-tasking.
TL;DR: This review considers some of the key advances that have been made in the understanding of the physiology, pathology and pharmacology of the glucocorticoids and the potential role of the steroids in the aetiology of disease.
Journal ArticleDOI
Progeny of mothers drinking corticosterone during lactation has lower stress-induced corticosterone secretion and better cognitive performance
Assia Catalani,Michela "Micky" Marinelli,Sergio Scaccianoce,Raffaella Nicolai,Luisa A. A. Muscolo,Alessandra Porcu,Lajos Korányi,Pier Vincenzo Piazza,Luciano Angelucci +8 more
TL;DR: It is demonstrated that a moderate increase in maternal corticosterone during lactation influences the activity of HPA axis and improves spatial learning ability of the adult offspring.
References
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Journal ArticleDOI
Rat Brain Binds Adrenal Steroid Hormone: Radioautography of Hippocampus with Corticosterone
John L. Gerlach,Bruce S. McEwen +1 more
TL;DR: The nuclei of many neurons were clearly labeled but radioactivity was relatively sparse in the cytoplasm, in the axons where they branch from cell bodies, and in adjacent neuropil.
Journal ArticleDOI
Telemetered Recording of Hormone Effects on Hippocampal Neurons
TL;DR: Frequency-modulated telemetry was used to record the effects of hormones on single-unit activity in the brains of freely moving rats and Corticosterone decreased unitActivity in the dorsal hippocampus.
Journal ArticleDOI
Effects of corticosteroids on the biochemical maturation of rat brain: postnatal cell formation.
TL;DR: Treatment with cortisol acetate (0.2 mg daily during the first 4 days after birth) reduced the rate of growth in the rat: at 35 days of age the body weight was reduced and the brain weight, depending on the region, was reduced by up to 30 per cent.
Journal ArticleDOI
Reductions in size and total DNA of cerebrum and cerebellum in adult mice after corticosterone treatment in infancy
TL;DR: The findings indicate that corticosterone given in infancy interfered with the synthesis of DNA, RNA, and protein in the brain, and produced an irreversible reduction in brain size and cell numbers, which was particularly marked in the cerebellum, because of the high rate of postnatal mitosis characteristic of certain cerebellar neurons.
Journal ArticleDOI
Some reflexes mediated by the afferent fibers of the abdominal vagus in the rabbit and cat.
B.G. Cragg,D.H.L. Evans +1 more
TL;DR: Adequate electrical stimulation of the central cut end of the abdominal vagus invariably raises the blood pressure due to visceral and somatic vasoconstriction without change of heart rate, accompanied by a reflex gastric relaxation which persists at reduced amplitude after abdominal vagotomy.
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Effects of corticosteroids on the biochemical maturation of rat brain: postnatal cell formation.
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