Journal ArticleDOI
Inbreeding and post-natal mortality in South India: Effects on the gene pool
TLDR
There were no significant differences between the various inbreeding classes in the number of liveborn or living children, nor was a significant consanguinity-related effect on the proportion of survivors detectable.Abstract:
Consanguineous marriages have been favoured throughout South India for many generations. On theoretical grounds it was proposed that long-term inbreeding would have resulted in the elimination of deleterious, recessive lethal and sub-lethal genes. As part of a newborn screening programme for amino acidopathies, data were collected on the level of inbreeding in the current populations of the cities of Bangalore and Mysore, and on the relationship between consanguinity and mean numbers of liveborn and living children. Mean cnonsanguinity was 32.24%, equivalent to a cuoefficient of inbreeding in the newborns,F = 00271. There were no significant differences between the various inbreeding classes in the number of liveborn or living children, nor was a significant consanguinity-related effect on the proportion of survivors detectable. In the light of these findings, the effects on the gene pool of multiple generations of inbreeding are discussed.read more
Citations
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Journal ArticleDOI
Neonatal screening for amino acidaemias in Karnataka, south India.
TL;DR: Blood samples obtained by toe‐stab from 98 256 neonates have been tested by thin layer chromatography, with 46 single and 70 general amino acidaemias detected, and the coefficients of inbreeding for the two groups of neonates were 0.0336 and 0.0350.
Journal ArticleDOI
A Demographic Profile of the People of Jammu and Kashmir 2. Estimates, Trends and Differentials in Fertility
M.K. Bhasin,Shampa Nag +1 more
TL;DR: In this article, an attempt is made to study the fertility patterns of various population groups from the state of Jammu and Kashmir and the relationship between fertility and ecological biological and socioeconomic factors are highlighted.
Journal ArticleDOI
Parental consanguinity and offspring mortality: the search for possible linkage in the Indian context.
TL;DR: This study attempts to provide some suitable answers to these questions by exploring the extent of stillbirths and the neonatal post-neonatal and child mortality rates among the offspring of consanguineous vis-a-vis non-consanguinity parents by controlling other important non-genetic proximate determinants of child mortality.
Journal ArticleDOI
Consanguinity, twinning and secondary sex ratio in the population of Karnataka, south India.
TL;DR: The results indicate that consanguinity is not associated with excess antenatal losses and suggest the possibility of enhanced selection against mutations at X chromosome loci.
Journal ArticleDOI
Consanguineous marriages and their effects on pregnancy outcomes in India
TL;DR: The results reveal that the occurrence of consanguineous marriages is more predominant in southern India and among socioeconomically disadvantageous groups and women inconsanguineously unions are more likely to have adverse pregnancy outcomes including stillbirths.
References
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The effects of inbreeding on Japanese children
William J. Schull,James V. Neel +1 more
TL;DR: The material is organized into 15 chapters and summarizes the differences between an average inbred and an outbred child and the relationship of the inbreeding results with the so-called "genetic load."
Journal Article
The effects of parental consanguinity and inbreeding in Hirado, Japan. V. Summary and interpretation.
W J Schull,J V Neel +1 more
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Inbreeding effects on human reproduction in Tamil Nadu of South India
P. S. S. Rao,S. G. Inbaraj +1 more
TL;DR: A prospective investigation of inbreeding effects was carried out during 1969‐74 on representative samples from rural and urban populations of Tamil Nadu in southern India, finding that in 80% or more of these marriages the spouses were first cousins or more closely related.
Journal ArticleDOI
Inbreeding in Tamil Nadu, South India.
P. S. S. Rao,S. G. Inbaraj +1 more
TL;DR: Although inbreeding levels have declined in most parts of the world, they are still high in South India, and data over the past several decades indicate that inbreeding continues to be maintained at relatively high levels even today.