H
Handanahal S. Savithri
Researcher at Indian Institute of Science
Publications - 204
Citations - 3565
Handanahal S. Savithri is an academic researcher from Indian Institute of Science. The author has contributed to research in topics: Serine hydroxymethyltransferase & Virus. The author has an hindex of 33, co-authored 201 publications receiving 3365 citations. Previous affiliations of Handanahal S. Savithri include Central Food Technological Research Institute & Purdue University.
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Journal ArticleDOI
Total peroxidase activity and peroxidase isoforms as modified by salt stress in two cultivars of fox-tail millet with differential salt tolerance
Nese Sreenivasulu,S. Ramanjulu,K Ramachandra-Kini,Harischandra Sripathy Prakash,H Shekar-Shetty,Handanahal S. Savithri,Chinta Sudhakar +6 more
TL;DR: A close correlation exists between the rate of lipid peroxidation in terms of malonaldehyde content and total peroxidase activity per gram fresh weight with salt tolerance of the two cultivars and an acidic isoperoxidases, A(3p) (27 kDa) is specifically found in the tolerant cultivar (cv Prasad) under NaCl stress.
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Structure-function relationship in serine hydroxymethyltransferase.
TL;DR: The mutational analysis of scSHMT along with the structure of recombinant Bacillus stearothermophilus SHMT and its substrate(s) complexes was used to provide evidence for a direct transfer mechanism rather than retro-aldol cleavage for the reaction catalyzed by SHMT.
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Evidence for recombination among the tomato leaf curl virus strains/species from Bangalore, India
TL;DR: The results indicate that there are potential sites of recombination in AV1, AV2, AC1 and intergenic regions of the viral genome and this accounts for the observed variability in these strains/species.
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Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism.
Vishal Trivedi,Amrita Gupta,Venkatakrishna R. Jala,P. Saravanan,G.S. Jagannatha Rao,N. Appaji Rao,Handanahal S. Savithri,Hosahalli Subramanya +7 more
TL;DR: In this paper, the first structure of the serine-bound form of SHMT has been presented, which allows identification of residues involved in serine binding and catalysis and provides evidence for a direct displacement mechanism for the hydroxymethyl transfer rather than a retroaldol cleavage.
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The self-assembly of the cowpea strain of southern bean mosaic virus: formation of T = 1 and T = 3 nucleoprotein particles.
TL;DR: The effects of pH and divalent cations on SBMV assembly suggest that the charge configuration of carboxyl group clusters in the putative initiation complex regulates further subunit interactions and, hence, the mode (T = 3 vs T = 1) of assembly.