Patent
Indolobenzazepine hcv ns5b inhibitors
Bergstrom Carl P,Bender John A,Robert G. Gentles,Piyasena Hewawasam,Thomas W. Hudyma,Kadow John F,Scott W. Martin,Alicia Regueiro-Ren,Kap-Sun Yeung,Yong Tu,Katharine A. Grant-Young,Xiaofan Zheng +11 more
TLDR
In this article, the authors describe compounds and salts of Formulas I, II, III, and IV as well as compositions and methods of using the compounds for hepatitis C virus (HCV).Abstract:
The invention encompasses compounds and salts of Formulas I, II, III, and IV as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.read more
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Hepatitis C virus inhibitors
Carol Bachand,Makonen Belema,Deon Daniel H,Andrew C. Good,Goodrich Jason,James Clint A,Lavoie Rico,Lopez Omar D,Alain Martel,Nicholas A. Meanwell,Van N. Nguyen,Jeffrey L. Romine,Ruediger Edward H,Lawrence B. Snyder,Denis R. St. Laurent,Fukang Yang,David R. Langley,Gan Wang,Lawrence G. Hamann +18 more
TL;DR: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection as mentioned in this paper, and also disclosed are pharmaceutical compositions containing such compounds and methods to use these compounds in the treatment.
Patent
Viral Polymerase Inhibitors
Youla S. Tsantrizos,Catherine Chabot,Pierre L. Beaulieu,Christian Brochu,Martin Poirier,Timothy A. Stammers,Bounkham Thavonekham,Rancourt Jean +7 more
TL;DR: An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof, as an inhibitor of HCV NS5B polymerase.
Patent
Macrocyclic hepatitis c serine protease inhibitors
Yi-Yin Ku,Mcdaniel Keith F,Hui-Ju Chen,Jason P. Shanley,Dale J. Kempf,David J. Grampovnik,Ying Sun,Dong Liu,Yonghua Gai,Yat Sun Or,Seble H. Wagaw,Kenneth M. Engstrom,Grieme Tim,Ahmad Y. Sheikh,Jianzhang Mei +14 more
TL;DR: In this paper, the authors proposed a method for treating a hepatitis C infection in a subject in need of such therapy with macrocyclic compounds, and further related to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutic acceptable carrier or excipient.
Patent
Compounds for the treatment of hepatitis c
Kap-Sun Yeung,Kyle Parcella,Bender John A,Brett R. Beno,Katharine A. Grant-Young,Han Ying,Piyasena Hewawasam,John F. Kadow,Andrew Nickel +8 more
TL;DR: In this paper, the authors have proposed compounds of formula I as well as compositions and methods of using the compounds, which have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.
Patent
Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors
TL;DR: The invention encompasses compounds of formula I as well as compositions and methods of using the compounds The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV as mentioned in this paper.
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Patent
Inhibitors of HCV replication
Thomas W. Hudyma,Xiaofan Zheng,Feng He,Min Ding,Bergstrom Carl P,Piyasena Hewawasam,Scott W. Martin,Robert G. Gentles +7 more
TL;DR: Indole compounds of Formula I are described in this paper and the compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV, and different forms and compositions comprising the compounds are also described as well as methods of preparing the compounds.
Patent
Tetracyclic indole derivatives as antiviral agents
TL;DR: In this article, a tetracyclic indole compounds of formula (I) were defined, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.
Patent
Fused heterotetracyclic compounds and use tehreof as hcv polymerase inhibitor
Takahiro Oka,Kazutaka Ikegashira,Shintaro Hirashima,Hiroshi Yamanaka,Satoru Noji,Yasushi Niwa,Yoko Matsumoto,Toshihiro Sato,Izuru Ando,Yukihiro Nomura +9 more
TL;DR: Fused heterotetracyclic compounds represented by the general formula [I], pharmaceutically acceptable salts thereof; and hepatitis C virus (HCV) polymerase inhibitors and remedies for hepatitis C containing the compounds: [I] (wherein each symbol is as defined in the description) as discussed by the authors.
Patent
R-enantiomers of pyranoindole derivatives against hepatitis c
TL;DR: In this paper, the authors describe a compound and a pharmaceutical composition of the formula: wherein substitutions at R1, R2, R3 - R12, and Y are set forth in the specification.
Related Papers (5)
Hepatitis C virus inhibitors
Carol Bachand,Makonen Belema,Deon Daniel H,Andrew C. Good,Goodrich Jason,James Clint A,Lavoie Rico,Lopez Omar D,Alain Martel,Nicholas A. Meanwell,Van N. Nguyen,Jeffrey L. Romine,Ruediger Edward H,Lawrence B. Snyder,Denis R. St. Laurent,Fukang Yang,David R. Langley,Gan Wang,Lawrence G. Hamann +18 more