Journal ArticleDOI
Induction of G2/M phase arrest and apoptosis of human leukemia cells by potent antitumor triazoloacridinone C-1305.
TLDR
C-1305 is a novel and potent compound which induces G2/M arrest and subsequent apoptosis of human leukemia cells and support the view that C-1304 could be consider as a new potent and promising antitumor agent.About:
This article is published in Biochemical Pharmacology.The article was published on 2006-12-15. It has received 33 citations till now. The article focuses on the topics: HL60 & Cytotoxic T cell.read more
Citations
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Mammalian caspases: structure ,a ctivation ,s ubstrates, and functions during apoptosis
TL;DR: Caspases, a family of cysteine-dependent aspartate-directed proteases, are prominent among the death proteases as discussed by the authors, and they play critical roles in initiation and execution of this process.
Journal ArticleDOI
Sequential induction of mitotic catastrophe followed by apoptosis in human leukemia MOLT4 cells by imidazoacridinone C-1311
TL;DR: Findings show that C-1311-induced mitotic catastrophe is not the ultimate death event but rather a step precipitating delayed, albeit massive, apoptotic responses.
Journal Article
Pterostilbene induces accumulation of autophagic vacuoles followed by cell death in HL60 human leukemia cells.
Kamila Siedlecka-Kroplewska,Agnieszka Jozwik,Wojciech Boguslawski,Michal Wozniak,Zauszkiewicz-Pawlak A,Jan Henryk Spodnik,Michał Rychłowski,Zbigniew Kmieć +7 more
TL;DR: It is found that treatment of HL60 cells with pterostilbene at the IC90 concentration resulted in the G0/G1 cell cycle arrest and accumulation of autophagic vacuoles followed by cell death in HL 60 cells.
Journal ArticleDOI
Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311: Highly Selective Substrates for UGT1A10
TL;DR: It is suggested that imid azoacrid inone and triazoloacridinone drugs are glucuronidated in human liver and intestine in vivo and may form the basis for future translational studies of the potential role of UGTs in resistance to these drugs.
Journal ArticleDOI
Pterostilbene induces cell cycle arrest and apoptosis in MOLT4 human leukemia cells.
Kamila Siedlecka-Kroplewska,Agnieszka Jozwik,Lucyna Kaszubowska,Anna Kowalczyk,Wojciech Boguslawski +4 more
TL;DR: Pterostilbene at the IC 90 concentration of 44 µM inhibited proliferation and induced apoptosis in MOLT4 human leukemia cells, suggesting that it could serve as an additional chemotherapeutic agent for the treatment of leukemia.
References
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Journal ArticleDOI
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
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Caspases: the executioners of apoptosis
TL;DR: The importance of caspase prodomains in the regulation of apoptosis is further highlighted by the recognition of adapter molecules, such as RAIDD [receptor-interacting protein (RIP)-associated ICH-1/CED-3-homologous protein with a death domain]/CRADD (caspase and RIP adapter with death domain), which binds to the prodomain of cspase-2 and recruits it to the signalling complex.
Journal ArticleDOI
Mitochondrial control of cell death
Guido Kroemer,John C. Reed +1 more
TL;DR: In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise, which has important consequences for the pathophysiology of cell death, as well as for its pharmacological control.
Journal ArticleDOI
Universal control mechanism regulating onset of M-phase
TL;DR: The onset of M-phase is regulated by a mechanism common to all eukaryotic cells and requires p34cdc2 dephosphorylation and association with cyclin.
Mammalian caspases: structure ,a ctivation ,s ubstrates, and functions during apoptosis
TL;DR: Caspases, a family of cysteine-dependent aspartate-directed proteases, are prominent among the death proteases as discussed by the authors, and they play critical roles in initiation and execution of this process.