Journal ArticleDOI
Induction of mania with selective serotonin re-uptake inhibitors and tricyclic antidepressants.
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TLDR
The rate of treatment-emergent switch into mania has been calculated from all available clinical trial data on the selective serotonin re-uptake inhibitors (SSRIs) fluoxetine, fluvoxamine, paroxetines, and sertraline, relative to comparative groups treated with tricyclic antidepressants (TCAs) or placebo.Abstract:
The rate of treatment-emergent switch into mania has been calculated from all available clinical trial data on the selective serotonin re-uptake inhibitors (SSRIs) fluoxetine, fluvoxamine, paroxetine, and sertraline, relative to comparative groups treated with tricyclic antidepressants (TCAs) or placebo. In predominantly unipolar depressives, the rate of manic switch is less than 1% and differences between drugs and placebo are statistically but not clinically significant. In bipolar depressives, manic switch occurs substantially more often with TCAs (11.2%) than with SSRIs (3.7%) or placebo (4.2%).read more
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Serotonin-norepinephrine reuptake inhibitor-associated mixed episode in an adolescent with schizoaffective disorder.
Jane Pei-Chen Chang,Jane Pei-Chen Chang,Mei Hung Chi,Yen Nan Chiu,Wen-Che Tsai,Susan Shur-Fen Gau,Chi-Yung Shang +6 more
Journal ArticleDOI
Depressive illness and the possibilities of somatic antidepressant treatment.
TL;DR: Different somatic antidepressant treatments for short- and long-term therapy and their respective quality-of-life and economic aspects will be presented and discussed.
Dissertation
Intravenous Delivery of a D1-D2 Interfering Peptide with Antidepressant-like Effects
TL;DR: This study finds that the D1-D2 interfering peptide has antidepressantlike effects compared to saline in rats in the forced swimming test at doses greater than 1.5nmol/g.
Incidence de virages maniaques chez les patients bipolaires hospitalisés traités avec des antidépresseurs
TL;DR: A retrospective descriptive study based on a review of 100 files of patients hospitalized for an episode of depression related to bipolar disorder at the Centre hospitalier de l'Universite Laval and treated with antidepressants from November 2001 to October 2007 as mentioned in this paper suggests that taking antidepressants such as paroxetine, venlafaxine, citalopram, and mirtazapine is associated with an increased risk of manic episodes.
References
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Journal ArticleDOI
Can antidepressants cause mania and worsen the course of affective illness
TL;DR: There appear to be no placebo-controlled studies of switches into mania in bipolar patients during antidepressant treatment, and the available evidence suggests that some bipolar patients become manic, and a few experience rapid cycling, when they are treated with antidepressants.
Journal ArticleDOI
The induction of mania. A natural history study with controls.
Jerry L. Lewis,George Winokur +1 more
TL;DR: The rate of induction of mania by TCAs is not greater than what one would expect from the natural history of the illness itself, and lithium carbonate and neuroleptic treatment, as expected, significantly prevented the induction ofMania.
Journal ArticleDOI
A controlled trial of imipramine in treatment of depressive states.
J. R. B. Ball,L. G. Kiloh +1 more
TL;DR: Information is provided on how to identify the components of serotonin, a substance which acts as a “spatially aggregating force” in women to increase the likelihood of fertility and increase the chance of pregnancy.
Journal ArticleDOI
A case of mania associated with fluoxetine.
Settle Ec,Settle Gp +1 more
TL;DR: A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine, and this side effect appears to be a universal property of effective antidepressants, including this new, purely serotonergic agent.
Journal ArticleDOI
Mania during fluoxetine treatment for recurrent depression.
Hon D,Sheldon H. Preskorn +1 more