Journal ArticleDOI
Induction of mania with selective serotonin re-uptake inhibitors and tricyclic antidepressants.
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TLDR
The rate of treatment-emergent switch into mania has been calculated from all available clinical trial data on the selective serotonin re-uptake inhibitors (SSRIs) fluoxetine, fluvoxamine, paroxetines, and sertraline, relative to comparative groups treated with tricyclic antidepressants (TCAs) or placebo.Abstract:
The rate of treatment-emergent switch into mania has been calculated from all available clinical trial data on the selective serotonin re-uptake inhibitors (SSRIs) fluoxetine, fluvoxamine, paroxetine, and sertraline, relative to comparative groups treated with tricyclic antidepressants (TCAs) or placebo. In predominantly unipolar depressives, the rate of manic switch is less than 1% and differences between drugs and placebo are statistically but not clinically significant. In bipolar depressives, manic switch occurs substantially more often with TCAs (11.2%) than with SSRIs (3.7%) or placebo (4.2%).read more
Citations
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Possible manic switch induced by combination of bupropion and electroconvulsive therapy in recurrent unipolar depression: a case series
TL;DR: Two patients with unipolar recurrent depression, with no family history of bipolarity or relevant personal medical history, who switched states while on a possible combination of bupropion and ECT are presented.
Journal ArticleDOI
Differential prevalence and demographic and clinical correlates of antidepressant use in American bipolar I versus bipolar II disorder patients.
Farnaz Hooshmand,Dennis Do,Saloni Shah,Anda Gershon,Dong Yeon Park,Hyun Ok Kim,Laura D. Yuen,Bernardo Dell'Osso,Po W. Wang,Terence A. Ketter,Shefali Miller +10 more
TL;DR: In this sample, antidepressant use was higher in BD II versus BD I patients, and was associated with markers of heightened illness severity in both BD I and BD II patients.
Journal ArticleDOI
Treatment of bipolar depression: focus on pharmacologic therapies.
Philip B. Mitchell,Gin S Malhi +1 more
TL;DR: The present status of treatments for bipolar depression is reviewed, highlighting emerging new pharmacotherapies such as lamotrigine, olanzapine and quetiapine, while also addressing modern psychologic interventions such as cognitive behavioral therapy and psychoeducation.
Journal ArticleDOI
First manic/hypomanic episode in obsessive-compulsive disorder patients treated with antidepressants: A systematic review.
Sara Bertolín,Pino Alonso,Cinto Segalàs,Eva Real,María Alemany-Navarro,Virginia Soria,Susana Jiménez-Murcia,José Manuel Crespo,José M. Menchón,José M. Menchón +9 more
TL;DR: In this article, a systematic literature review was performed on manic/hypomanic episodes in non-bipolar OCD patients using descriptive statistics and clinical, sociodemographic and antidepressant characteristics during the manic and hypomanic switch.
References
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Journal ArticleDOI
Can antidepressants cause mania and worsen the course of affective illness
TL;DR: There appear to be no placebo-controlled studies of switches into mania in bipolar patients during antidepressant treatment, and the available evidence suggests that some bipolar patients become manic, and a few experience rapid cycling, when they are treated with antidepressants.
Journal ArticleDOI
The induction of mania. A natural history study with controls.
Jerry L. Lewis,George Winokur +1 more
TL;DR: The rate of induction of mania by TCAs is not greater than what one would expect from the natural history of the illness itself, and lithium carbonate and neuroleptic treatment, as expected, significantly prevented the induction ofMania.
Journal ArticleDOI
A controlled trial of imipramine in treatment of depressive states.
J. R. B. Ball,L. G. Kiloh +1 more
TL;DR: Information is provided on how to identify the components of serotonin, a substance which acts as a “spatially aggregating force” in women to increase the likelihood of fertility and increase the chance of pregnancy.
Journal ArticleDOI
A case of mania associated with fluoxetine.
Settle Ec,Settle Gp +1 more
TL;DR: A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine, and this side effect appears to be a universal property of effective antidepressants, including this new, purely serotonergic agent.
Journal ArticleDOI
Mania during fluoxetine treatment for recurrent depression.
Hon D,Sheldon H. Preskorn +1 more