Inflammatory Bowel Disease and Risk of Colorectal Cancer: An Overview From Pathophysiology to Pharmacological Prevention.
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The authors in this paper summarized the current knowledge of IBD-CRC, focusing on the main mechanisms underlying its pathogenesis, and on the important role of immunomodulators and biologics used to treat IBD patients in interfering with the inflammatory process involved in carcinogenesis.Abstract:
Increased risk of colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients has been attributed to long-standing chronic inflammation, with the contribution of genetic alterations and environmental factors such as the microbiota. Moreover, accumulating data indicate that IBD-associated CRC (IBD-CRC) may initiate and develop through a pathway of tumorigenesis distinct from that of sporadic CRC. This mini-review summarizes the current knowledge of IBD-CRC, focusing on the main mechanisms underlying its pathogenesis, and on the important role of immunomodulators and biologics used to treat IBD patients in interfering with the inflammatory process involved in carcinogenesis.read more
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Genomic alterations in colitis-associated cancers in comparison to those found in sporadic colorectal cancer and present in precancerous dysplasia.
Walid K. Chatila,Henry Walch,Jamal Benhamida,Jaclyn F. Hechtman,Francisco M. Barriga,Ritika Kundra,Dorina Ismalgeci,Vincent A. Miller,Karuna Ganesh,David Faleck,Nikolaus Schultz,Laura H. Tang,David P. Kelsen,Rona Yaeger +13 more
TL;DR: Patients with inflammatory bowel disease and ulcerative colitis are at increased risk for small bowel or colorectal cancers (Colitis Associated Canc...
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