G
Gabriele Stocco
Researcher at University of Trieste
Publications - 118
Citations - 2312
Gabriele Stocco is an academic researcher from University of Trieste. The author has contributed to research in topics: Inflammatory bowel disease & Thiopurine methyltransferase. The author has an hindex of 22, co-authored 108 publications receiving 1901 citations. Previous affiliations of Gabriele Stocco include Boston Children's Hospital & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia
Gabriele Stocco,Gabriele Stocco,Meyling Cheok,Kristine R. Crews,Thierry Dervieux,Deborah L. French,Deqing Pei,Wenjian Yang,C. Cheng,C H Pui,Mary V. Relling,William E. Evans +11 more
TL;DR: Genetic polymorphism of ITPA is a significant determinant of mercaptopurine metabolism and of severe febrile neutropenia, after combination chemotherapy for ALL in which merc laptopurine doses are individualized on the basis of TPMT genotype.
Journal ArticleDOI
Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia.
Jun J. Yang,Deepa Bhojwani,Deepa Bhojwani,Wenjian Yang,Xiangjun Cai,Gabriele Stocco,Kristine R. Crews,Jinhua Wang,Debra J. Morrison,Meenakshi Devidas,Stephen P. Hunger,Cheryl L. Willman,Elizabeth A. Raetz,Ching-Hon Pui,William E. Evans,Mary V. Relling,William L. Carroll +16 more
TL;DR: In an independent cohort of children with ALL, reduced expression of MSH6 was associated with resistance to mercaptopurine and prednisone, thereby providing a plausible mechanism by which this acquired deletion contributes to drug resistance at relapse.
Journal ArticleDOI
Type I interferon-mediated autoinflammation due to DNase II deficiency
Mathieu P Rodero,Alessandra Tesser,Eva Bartok,Gillian I. Rice,Erika Della Mina,Marine Depp,Benoit Beitz,Vincent Bondet,Vincent Bondet,Nicolas Cagnard,Darragh Duffy,Darragh Duffy,Michael Dussiot,Marie-Louise Frémond,Marco Gattorno,Flavia Guillem,Naoki Kitabayashi,Fabrice Porcheray,Frédéric Rieux-Laucat,Frédéric Rieux-Laucat,Luis Seabra,Carolina Uggenti,Stefano Volpi,Leo A. H. Zeef,Marie Alexandra Alyanakian,Jacques Beltrand,Jacques Beltrand,Anna Monica Bianco,Nathalie Boddaert,Nathalie Boddaert,Chantal Brouzes,Sophie Candon,Roberta Caorsi,Marina Charbit,Monique Fabre,Flavio Faletra,Muriel Girard,Muriel Girard,Annie Harroche,Evelyn Hartmann,Evelyn Hartmann,Dominique Lasne,Dominique Lasne,Annalisa Marcuzzi,Bénédicte Neven,Bénédicte Neven,Bénédicte Neven,Patrick Nitschke,Tiffany Pascreau,Tiffany Pascreau,Serena Pastore,Capucine Picard,Paolo Picco,Elisa Piscianz,Michel Polak,Michel Polak,Pierre Quartier,Pierre Quartier,Pierre Quartier,Marion Rabant,Gabriele Stocco,Andrea Taddio,Florence Uettwiller,Florence Uettwiller,Florence Uettwiller,Erica Valencic,Diego Vozzi,Gunther Hartmann,Winfried Barchet,Olivier Hermine,Brigitte Bader-Meunier,Brigitte Bader-Meunier,Alberto Tommasini,Yanick J. Crow +73 more
TL;DR: Loss-of-function mutations in the DNASE2 gene are identified that cause type I interferon-mediated autoinflammation due to enhanced systemicinterferon signaling and are defined as a type I Interferonopathy due to DNase II deficiency in humans.
Journal ArticleDOI
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.
Steven W. Paugh,Erik J. Bonten,Daniel Savic,Laura B. Ramsey,William E. Thierfelder,Prajwal Gurung,R. K. Subbarao Malireddi,Marcelo Actis,Anand Mayasundari,Jaeki Min,David R. Coss,Lucas T. Laudermilk,John C. Panetta,J. Robert McCorkle,Yiping Fan,Kristine R. Crews,Gabriele Stocco,Mark R. Wilkinson,Antonio M. Ferreira,Cheng Cheng,Wenjian Yang,Seth E. Karol,Christian A. Fernandez,Barthelemy Diouf,Colton Smith,J. Kevin Hicks,Alessandra Zanut,Audrey Giordanengo,Daniel J. Crona,Joy J. Bianchi,Linda Holmfeldt,Charles G. Mullighan,Monique L. den Boer,Rob Pieters,Sima Jeha,Thomas L. Dunwell,Farida Latif,Deepa Bhojwani,William L. Carroll,Ching-Hon Pui,Richard M. Myers,R. Kiplin Guy,Thirumala-Devi Kanneganti,Mary V. Relling,William E. Evans +44 more
TL;DR: A new mechanism by which the NLRP3-CASP1 inflammasome modulates cellular levels of the glucocorticoid receptor and diminishes cell sensitivity to glucOCorticoids is established.
Journal ArticleDOI
Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease.
Gabriele Stocco,Stefano Martelossi,Arrigo Barabino,Giuliana Decorti,Fiora Bartoli,Marcella Montico,Annalisa Gotti,Alessandro Ventura +7 more
TL;DR: Patients with IBD with a wildtype GST‐M1 genotype present increased probability of developing adverse effects and increased incidence of lymphopenia during azathioprine treatment.