Journal ArticleDOI
Influence of etiology of atrial fibrillation on incidence of systemic embolism.
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TLDR
A study of embolic occurrences in 333 autopsy patients with atrial fibrillation associated with various kinds of heart disease suggests a high risk of embolism from atrialfibrillation of any origin, but particularly from that caused by ischemic heart disease and mitral valve disease.Abstract:
Atrial fibrillation is well known to increase greatly the risk of systemic arterial embolism in patients with mitral valve disease. In light of the clinical frequency of embolism in patients with atrial fibrillation due to other types of heart disease, a study was made of embolic occurrences in 333 autopsy patients with atrial fibrillation associated with various kinds of heart disease. Considering only symptomatic emboli with pathologic or surgical confirmation, embolism occurred in 41% of patients with mitral valve disease, 35% of those with ischemic heart disease, 35% of those with coexisting mitral and ischemic heart disease and 17% of those with "other" types of heart disease. Embolism was found in only 7% of a control group of 58 autopsy patients with ischemic heart disease without atrial fibrillation. These findings suggest a high risk of embolism from atrial fibrillation of any origin, but particularly from that caused by ischemic heart disease and mitral valve disease.read more
Citations
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Journal ArticleDOI
Stroke Prevention in Atrial Fibrillation Study. Final results.
TL;DR: Aspirin and warfarin are both effective in reducing ischemic stroke and systemic embolism in patients with atrial fibrillation and patients with nonrheumatic atrialfibrillation who can safely take either aspirin or warfarIn should receive prophylactic antithrombotic therapy to reduce the risk of stroke.
Journal ArticleDOI
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The Framingham Study
TL;DR: Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.
Journal ArticleDOI
Atrial Fibrillation: A Major Contributor to Stroke in the Elderly. The Framingham Study
TL;DR: In contrast to the impact of cardiac failure, coronary heart disease, and hypertension, which declined with age, atrial fibrillation was a significant contributor to stroke at all ages.
Journal ArticleDOI
The effect of low-dose warfarin on the risk of stroke in patients with nonrheumatic atrial fibrillation.
Daniel E. Singer,Robert A. Hughes,Gress Dr,Mary A. Sheehan,Lynn B. Oertel,S W Maraventano,Blewett Dr,Bernard Rosner,Joerg Kistler +8 more
TL;DR: Long-term low-dose warfarin therapy is highly effective in preventing stroke in patients with non-rheumatic atrial fibrillation, and can be quite safe with careful monitoring.
Journal ArticleDOI
Characteristics and Prognosis of Lone Atrial Fibrillation: 30-Year Follow-up in the Framingham Study
TL;DR: It is suggested that subjects with lone AF, despite similar cardiovascular risk profiles to normal controls, have a distinct preponderance of preexisting electrocardiographic abnormalities.
References
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Systemic embolism in mitral valve disease.
TL;DR: The analysis of a series of 839 cases of mitral valve disease has shown that systemic embolism is as common with mitral regurgitation as with Mitral stenosis, and only in patients with atrial fibrillation and an operable valve, is there any reduction in the number of emboli after surgery.
Journal ArticleDOI
Systemic arterial embolism in rheumatic heart disease.
TL;DR: The considerable progress in the past few years with anticoagulant agents as a protection against embolism and the recent surgical obliteration of the left atrial appendage as a possible focus of thrombus formation in rheumatic heart disease were responsible for the present study.