Journal ArticleDOI
Interferon treatment in patients with chronic hepatitis B: A meta-analysis of the published literature
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TLDR
It is concluded that the effectiveness of interferon in patients with chronic hepatitis B has yet to be confirmed by long-term prospective studies which assess the outcome by clinically meaningful end points such as cirrhosis, liver failure, or death.About:
This article is published in Journal of Hepatology.The article was published on 1993-01-01. It has received 85 citations till now. The article focuses on the topics: Clinical trial & Cirrhosis.read more
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Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B.
Claus Niederau,Tobias Heintges,Stefan Lange,Georg Goldmann,Christoph M. Niederau,Leonhard Mohr,Dieter Häussinger +6 more
TL;DR: In patients with chronic hepatitis B infection, the clearance of HBeAg after treatment with interferon alfa is associated with improved clinical outcomes, and overall survival and survival without clinical complications were significantly longer in patients who were seronegative for H beAg after therapy withInterferonAlfa.
Journal ArticleDOI
EASL International Consensus Conference on Hepatitis B. 13-14 September, 2002 Geneva, Switzerland. Consensus statement (long version).
TL;DR: The aim of this concert is to inspire a new generation of public speakers andators and to contribute towards the humanizing of classical music.
Easl international consensus conference on hepatitis b
TL;DR: International experts in the field of virology, epidemiology, natural history, prevention, and the treatment of hepatitis B provided 2 days of presentation and discussions at EASL to define the state of knowledge and to elaborate recommendations for the management of patients with hepatitis B.
Journal ArticleDOI
Assessing the quality of reports of randomised trials: implications for the conduct of meta-analyses.
David Moher,Deborah J. Cook,Alejandro R. Jadad,Peter Tugwell,Michael Moher,Anamaria Jones,B Pham,Terry P. Klassen +7 more
TL;DR: This work aims to provide a database of systematic reviews of systematic Reviews of Pediatrics and Biostatistics for use in clinical practice and aims to rank the reviews according to their quality and adequacy.
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The long‐term course of chronic hepatitis B
Vito Di Marco,Oreste Lo Iacono,Calogero Cammà,Alessandra Vaccaro,Marco Giunta,G. Martorana,Patrizia Fuschi,Piero Luigi Almasio,Antonio Craxì +8 more
TL;DR: Chronic hepatitis B infection increases mortality in comparison with the general population in the authors' area regardless of specific virological profiles at presentation, and presence of cirrhosis and persistent necroinflammation markedly increase the risk of death.
References
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Summing Up: The Science of Reviewing Research
TL;DR: A Checklist for Evaluating Reviews Reference Index as discussed by the authors is a checklist for evaluating reviews that is based on a reviewing strategy and a review review strategy that is organized by the division of labor.
Journal ArticleDOI
A method for assessing the quality of a randomized control trial.
Thomas C. Chalmers,Harry Smith,Bradley Blackburn,Bernard Silverman,Biruta Schroeder,Dinah Reitman,Alexander Ambroz +6 more
TL;DR: A reasonable standard design and conduct of trials will facilitate the interpretation of those with conflicting results and help in making valid combinations of undersized trials.
Journal ArticleDOI
Summing Up: The Science of Reviewing Research.
TL;DR: In this article, the authors summarize the science of reviewing research, including the review process, the review review process itself, and the reviewer's role in reviewing research articles, as well as the process of reviewing the review articles.
Journal ArticleDOI
Meta-analyses of randomized controlled trials.
TL;DR: It is concluded that an urgent need exists for improved methods in literature searching, quality evaluation of trials, and synthesizing of the results.
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Meta-analysis in clinical research.
TL;DR: Important design and statistical issues of this process of combining study results that can be used to draw conclusions about therapeutic effectiveness or to plan new studies are reviewed.