Showing papers in "Journal of Hepatology in 1993"

TL;DR: The high prevalence of anti-HCV detected in HCC suggests that HCV is a major co-factor in the development of HCC and again raises the issue of viral persistence and neoplastic transformation, an issue that for HBV has not yet been elucidated.

TL;DR: The results indicate that bacterial infection is a severe complication in the course of cirrhosis, and Child-Pugh classification showed a predominance of class C in infected cirrhotic patients compared to non-infected ones.

TL;DR: It was found that HCV-PT, the prototype reported from the U.S.A., was rare in Japan, suggesting that distribution of HCV genotypes may be different in various countries, and the prevalence of HCVs genotypes was compared in different countries.

TL;DR: In this paper, two sets of prognostic indicators were recently proposed for selection of patients with acute liver failure for emergency liver transplantation, and the predictive accuracies, respectively on admission and 48 h before death, were 0.80 and 0.73 for the Clichy criteria.

TL;DR: Reduction of serum alpha-fetoprotein (AFP) to normal levels does not exclude a later recurrence (7 of 17 cases) and this was documented after maintenance of normal AFP levels for up to 29 months.(ABSTRACT TRUNCATED at 250 WORDS)

TL;DR: In this article, the authors found that primary biliary cirrhosis (PBC) recurring after orthotopic liver transplantation (OLT) was looked for in a 'blinded' study of 353 biopsies from 188 patients, 12-100 months post-transplant.

TL;DR: As the endemicity of HAV transmission decreases, the reported rate of clinical hepatitis A can increase, due to the shift in the average age of infection to an age when clinical illness is more frequent, and disease patterns may change.

TL;DR: Cytomegalovirus infection was a risk factor for the development of severe bacterial infections and a multivariate time-dependent analysis and the treatment with OKT3 therapy and hepatic artery thrombosis were found to be significant risk factors.

TL;DR: It is demonstrated that TIPS is a feasible treatment of Budd-Chiari syndrome that restores splanchnic blood flow, reduces collateral circulation and ascites and provides sufficient time to allow for elective liver transplantation, if indicated.

TL;DR: In some chronic hepatitis C patients the pattern and the titer of autoantibodies may create confusion with an autoimmune chronic active hepatitis, and there is no serological evidence for a hepatitis C virus infection in true type-2 autoimmune chronicactive hepatitis.

TL;DR: Based on results from extensive clinical research, interferon-α-2a (IFN-α 2a, Roferon ® -A, F. Hoffmann-LaRoche Ltd., Switzerland) and other interferons have been registered for the treatment of chronic active hepatitis B.

TL;DR: In an American referral population autoimmune hepatitis usually lacks virologic markers and has a distinctive clinical, immunoserologic and HLA phenotype and Hepatitis viruses are unlikely to be important causes of this form of autoimmune hepatitis.

TL;DR: In this article, the safety and efficacy of long-term oral supplementation with branched-chain amino acids as an adjunct to conventional therapy in patients with stable cirrhosis and latent encephalopathy was assessed.

TL;DR: D dose-dependent effects of ornithine aspartate (OA) on postprandial hyperammonemia and plasma amino acids and urea production rate, serum glucose and serum insulin were analyzed and glutamate showed a rise in its plasma level following infusion of 40 g of OA, whereas glutamine did not.

TL;DR: ICP monitoring proved safe and effective, provided valuable information regarding subclinical intracranial hypertension and prognosis and should be regarded as part of the routine management of intrac Cranial hypertension complicating FHF.

TL;DR: Interferon diminishes inflammatory and fibrogenic activity in the majority of patients with chronic hepatitis C and abolishes viremia in most of the patients with a sustained response, representing a long-term sustained remission of the disease.

TL;DR: Patients with recurrent urinary tract infections, all of whom had normal liver function and were taking prophylactic antibiotic treatment, had weak anti-mitochondrial antibody (AMA) reactivity, with reactivity against the 74-kD antigen alone being the most common.

TL;DR: The α 1 -ACT deficiency state may predispose to obstructive lung disease and influence the course of liver disease, and identification of a specific mutation allows identification of heterozygotes for this deficiency allowing future evaluation of its clinical significance.

TL;DR: Plugged-percutaneous liver biopsy provides larger biopsies but may be associated with an increased risk of haemorrhage, while transjugular biopsy was associated with a high success rate and a low incidence of complications.

TL;DR: It is concluded that the effectiveness of interferon in patients with chronic hepatitis B has yet to be confirmed by long-term prospective studies which assess the outcome by clinically meaningful end points such as cirrhosis, liver failure, or death.

TL;DR: In this paper, the authors describe and classify the vascular abnormalities of the gastric wall as observed on echo-endoscopy in cirrhotic patients and compare the data with endoscopy.

TL;DR: Because large varices are unlikely to develop de novo within 2 years, biennial endoscopic screening is sufficient for patients without varices; annual endoscopy is recommended for those with small varices.

TL;DR: The clinical significance of a semi-quantitative microparticle enzyme immunoassay (IMx Core-M, Abbott) was evaluated for detection of IgM-class antibodies against the hepatitis B core antigen (IgM anti-HBc) in 136 hepatitis B surface antigen (HBsAg) positive individuals.

TL;DR: The worldwide experience to date with VAQTA, a highly purified formalin-inactivated hepatitis A vaccine containing alum-adjuvant, is reviewed, and seroconversion induced by this vaccine has been shown to signify protection from clinical hepatitis A disease.

TL;DR: In conclusion, about half of the patients with chronic hepatitis C who are unresponsive to alpha-interferon show a clear-cut biochemical response after 6-9 months of ribavirin administration, however, Ribavirin does not clear circulating hepatitis C virus RNA and relapses occur after withdrawal.

TL;DR: In this paper, the authors investigated plasma concentrations of endothelin-1 in different vascular beds in relation to clinical and biochemical parameters of liver function, and no significant differences were found in ET-1 plasma concentrations between the liver, renal, or femoral veins on the one hand and the femoral artery on the other (P > 0.1).

TL;DR: The MEGX formation test reflects the severity of hepatic dysfunction quite well, making it valuable both in the quantitative evaluation of liver function and in the prognostic prediction of adults with liver diseases.

TL;DR: In this article, the effects of nocturnal oral glucose supplements on nitrogen metabolism were investigated in 8 cirrhotic patients and in 8 healthy controls during the night, either polymeric glucose was given or water as placebo.

TL;DR: It is suggested that alpha-IFN treatment may decrease stimuli for fibrogenesis by reducing liver inflammation and necrosis, thus preventing evolution to cirrhosis.

TL;DR: In this article, the role of iron in liver cell damage from alcohol was investigated in a rat pair-fed with a liquid ethanol diet for 4 weeks, where the liver liver iron content was 6.4 vs. 0.5 μg Fe/mg protein in the controls.