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Intraperitoneal free cancer cells and their viability in gastric cancer

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TLDR
The viability of free cancer cells in the peritoneal cavity was relatively high, but could be suppressed remarkably by intraperitoneal administration of 10 mg of mitomycin‐C.
Abstract
Free cancer cells in the peritoneal cavity of 100 patients with gastric cancer were examined by means of Douglas lavage, and their viability was estimated by 3H-thymidine uptake with autoradiographical technic. Furthermore, the effect of mitomycin-C on the viability of free cancer cells in the peritoneal cavity was studied. The appearance of intraperitoneal free cancer cells was dependent on the degree of invasion of cancer to the gastric serosa; that is, free cancer cells were not found in cases without serosal invasion, but were found in 48% with serosal invasion. The viability of free cancer cells in the peritoneal cavity was relatively high, but could be suppressed remarkably by intraperitoneal administration of 10 mg of mitomycin-C.

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Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study.

TL;DR: In this paper, the authors investigated the progression of pancreatic and gastric peritoneal carcinomatosis (PC) from non-gynecologic malignancies, and found that the survival rates were mainly affected by the initial stage (98 months for Stage I with malignant peritone granulations less than 5 mm in greatest dimension, versus 37 months for stage IV with large, malignant malignancy more than 2 cm in largest dimension) The presence of ascites was associated with poor survival of patients with gastric or pancreatic carcinoma Differentiation of the
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Abdominal wall metastases following laparoscopy.

TL;DR: Only 18 cases of recurrence at the sites of cannula insertion after laparoscopy have been reported in the literature, but there may be increased exfoliation of tumour cells following manipulation by laparoscopic instruments of an unsuspected malignancy.
Journal ArticleDOI

Peritoneal carcinomatosis from digestive tract cancer: new management by cytoreductive surgery and intraperitoneal chemohyperthermia

TL;DR: IPCH combined with cytoreductive surgery seems to be an effective therapeutic approach in carefully selected patients, and offers a chance for cure or palliation in this condition with few alternative treatment options.
Journal ArticleDOI

Intraperitoneal chemohyperthermia using a closed abdominal procedure and cytoreductive surgery for the treatment of peritoneal carcinomatosis: morbidity and mortality analysis of 216 consecutive procedures.

TL;DR: The frequency of complications after IPCH and cytoreductive surgery was mainly associated with the carcinomatosis stage and the extent of the surgical procedure, and the IPCH closed abdominal procedure has shown an acceptable frequency of adverse events.
Journal ArticleDOI

Intraoperative lavage for cytological examination in 1,297 patients with gastric carcinoma

TL;DR: Multivariate analyses indicated that intraoperative cytological findings was an independent prognostic factor for survival, and was the most important factor for predicting peritoneal recurrence in gastric cancer.
References
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Journal ArticleDOI

Cell viability studies on the exfoliated colonic cancer cell

TL;DR: None of the exfoliated colonic cancer cell suspensions had viable cells, which would cast some doubt on the hypothesis that suture line recurrence following large bowel cancer surgery is due to the implantation of cells desquamated from the surface of the growth.
Journal ArticleDOI

Postoperative recurrence of cancer of colon due to desquamated malignant cells.

Alfred A. Pomeranz, +1 more
- 20 Aug 1955 - 
TL;DR: In a recent review of suture line recurrences after anterior resection of the rectum, Goligher and associates 1 concluded that in at least half of these 23 cases the recurrence was not due to incomplete resections of intramurally spread tumor but to the possible local implantation of viable cancer cells.
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