Is subendocardial ischaemia present in patients with chest pain and normal coronary angiograms? A cardiovascular MR study.
Ilse A C Vermeltfoort,O. Bondarenko,Pieter G. Raijmakers,Diego A M Odekerken,Aaf F M Kuijper,A. Zwijnenburg,Mary J E van der Vis-Melsen,Jos W. R. Twisk,Aernout M. Beek,Gerrit J.J. Teule,Albert C. van Rossum +10 more
TLDR
The results show that patients with chest pain and normal coronary angiograms had significant perfusion responses to adenosine in both the subendocardium and subepicardium, and the index for myocardial perfusion reserve (MPRI) was 1.50.Abstract:
I read with interest the recent article by Vermeltfoort et al , 1 on the use of dynamic contrast enhancement in MRI to evaluate the possible presence of subendocardial ischaemia in patients with chest pain and normal coronary arteries (‘syndrome X’) Their conclusion, that they found no evidence of subendocardial hypoperfusion with adenosine stress in these patients, is in striking contrast to a previous report by Panting et al , 2 who found evidence of a failure of the perfusion of the …read more
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Women and ischemic heart disease: evolving knowledge.
TL;DR: It is hypothesize that women experience more adverse outcomes compared with men because obstructive CAD remains the current focus of therapeutic strategies and antianginal and anti-ischemic therapies can improve symptoms, endothelial function, and quality of life.
Journal ArticleDOI
Myocardial first-pass perfusion cardiovascular magnetic resonance: history, theory, and current state of the art.
Bernhard Gerber,Subha V. Raman,Krishna S. Nayak,Frederick H. Epstein,Pedro F. Ferreira,Leon Axel,Dara L. Kraitchman +6 more
TL;DR: This comprehensive overview includes a summary of the past clinical performance of first-pass perfusion CMR and current clinical applications using state-of-the-art methodologies.
Journal ArticleDOI
Role of Noninvasive Testing in the Clinical Evaluation of Women With Suspected Ischemic Heart Disease A Consensus Statement From the American Heart Association
Jennifer H. Mieres,Martha Gulati,Noel Bairey Merz,Daniel S. Berman,Thomas C. Gerber,Sharonne N. Hayes,Christopher M. Kramer,James K. Min,L. Kristin Newby,J.V. (Ian) Nixon,Monvadi B. Srichai,Patricia A. Pellikka,Rita F. Redberg,Nanette K. Wenger,Leslee J. Shaw +14 more
TL;DR: The present statement provides an update to the 2005 document and synthesizes contemporary evidence on appropriate symptomatic female candidates for diagnostic testing, as well as sex-specific data on the diagnostic and prognostic accuracy for exercise treadmill testing with electrocardiography and stress echocardiography.
Journal ArticleDOI
Cardiac magnetic resonance myocardial perfusion reserve index is reduced in women with coronary microvascular dysfunction. A National Heart, Lung, and Blood Institute-sponsored study from the Women's Ischemia Syndrome Evaluation.
Louise Thomson,Janet Wei,Megha Agarwal,Afsaneh Haftbaradaran,Chrisandra Shufelt,Puja K. Mehta,Edward Gill,B. Delia Johnson,Tanya S. Kenkre,Eileen M. Handberg,Debiao Li,Behzad Sharif,Daniel S. Berman,John W. Petersen,Carl J. Pepine,C. Noel Bairey Merz +15 more
TL;DR: In this article, women with signs and symptoms of ischemia and no obstructive coronary artery disease often have coronary microvascular dysfunction (CMD), diagnosed by invasive coronary reactivity testin...
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Relation between stress-induced myocardial perfusion defects on cardiovascular magnetic resonance and coronary microvascular dysfunction in patients with cardiac syndrome X.
Gaetano Antonio Lanza,Antonino Buffon,Alfonso Sestito,Luigi Natale,Gregory A. Sgueglia,L. Galiuto,Fabio Infusino,Luca Mariani,Antonio Centola,Filippo Crea +9 more
TL;DR: DST-induced myocardial perfusion defects on CMR and reduced CFR in the LAD coronary artery territory in CSX patients are shown, thus giving strong evidence that a dysfunction of coronary microcirculation resulting in myocardian perfusion abnormalities is present in these patients.
References
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American College of Radiology white paper on radiation dose in medicine.
E. Stephen Amis,Priscilla F. Butler,Kimberly E. Applegate,Steven Birnbaum,Libby Brateman,James M. Hevezi,Fred A. Mettler,Richard L. Morin,Michael J. Pentecost,Geoffrey G. Smith,Keith J. Strauss,Robert K. Zeman +11 more
TL;DR: This white paper details a proposed action plan for the college derived from the deliberations of the ACR Blue Ribbon Panel on Radiation Dose in Medicine and reflects the findings of that panel.
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Abnormal Subendocardial Perfusion in Cardiac Syndrome X Detected by Cardiovascular Magnetic Resonance Imaging
Jonathan R. Panting,Peter D. Gatehouse,Guang-Zhong Yang,Frank Grothues,David N. Firmin,Peter Collins,Dudley J. Pennell +6 more
TL;DR: Cardiovascular magnetic resonance imaging demonstrates subendocardial hypoperfusion during the intravenous administration of adenosine, which is associated with intense chest pain, and supports the notion that the chest pain may have an ischemic cause.
Journal ArticleDOI
Magnetic Resonance Perfusion Measurements for the Noninvasive Detection of Coronary Artery Disease
Eike Nagel,Christoph Klein,Ingo Paetsch,Sabine Hettwer,Bernhard Schnackenburg,Karl Wegscheider,Eckart Fleck +6 more
TL;DR: The determination of MPRI with MRI yields a high diagnostic accuracy in patients with suspected CAD, and is able to differentiate ischemic and nonischemic segments.