Open AccessBook
Coronary Microvascular Dysfunction
Paolo G. Camici,Filippo Crea +1 more
TLDR
This review discusses the pathogenesis and management of coronary microvascular dysfunction and factors to consider in clinical management are the cause of the dysfunction and whether it is iatrogenic, whether obstructive coronary artery disease is present, and whether myocardial disease ispresent.Abstract:
This review discusses the pathogenesis and management of coronary microvascular dysfunction. Factors to consider in clinical management are the cause of the dysfunction and whether it is iatrogenic, whether obstructive coronary artery disease is present, and whether myocardial disease is present.read more
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2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology.
Gilles Montalescot,Udo Sechtem,Stephan Achenbach,Felicita Andreotti,Chris Arden,Andrzej Budaj,Raffaele Bugiardini,Filippo Crea,Thomas Cuisset,Carlo Di Mario,J. Rafael Ferreira,Bernard J. Gersh,Anselm K. Gitt,Jean-Sébastien Hulot,Nikolaus Marx,Lionel H. Opie,Matthias Pfisterer,Eva Prescott,Frank Ruschitzka,Manel Sabaté,Roxy Senior,David P. Taggart,Ernst E. van der Wall,Christiaan J. Vrints,José Luis Zamorano,Helmut Baumgartner,Jeroen J. Bax,Héctor Bueno,Veronica Dean,Christi Deaton,Çetin Erol,Robert Fagard,Roberto Ferrari,David Hasdai,Arno W. Hoes,Paulus Kirchhof,Juhani Knuuti,Philippe Kolh,Patrizio Lancellotti,Aleš Linhart,Petros Nihoyannopoulos,Massimo F Piepoli,Piotr Ponikowski,Per Anton Sirnes,Juan Tamargo,Michal Tendera,Adam Torbicki,William Wijns,Stephan Windecker,Marco Valgimigli,Marc J. Claeys,Norbert Donner-Banzhoff,Herbert Frank,Christian Funck-Brentano,Oliver Gaemperli,José Ramón González-Juanatey,Michalis Hamilos,Steen Husted,Stefan James,Kari Kervinen,Steen Dalby Kristensen,Aldo P. Maggioni,Axel R. Pries,Francesco Romeo,Lars Rydén,Maarten L. Simoons,Ph. Gabriel Steg,Adam Timmis,Aylin Yildirir +68 more
TL;DR: The If Inhibitor Ivabradine in Patients With Coronary Artery Disease and Left Ventricular Dysfunction is evaluated as well as patients with Diabetes mellitus for Optimal management of Multivessel disease.
Journal ArticleDOI
The Assessment of Endothelial Function From Research Into Clinical Practice
Andreas J. Flammer,Todd J. Anderson,David S. Celermajer,Mark A. Creager,Mark A. Creager,John E. Deanfield,Peter Ganz,Naomi M. Hamburg,Thomas F. Lüscher,Michael Shechter,Stefano Taddei,Joseph A. Vita,Amir Lerman +12 more
TL;DR: The assessment of its vasodilator properties resulting from NO and other molecules may provide information on the integrity and function of the endothelium, and most, if not all, cardiovascular risk factors are associated with endothelial dysfunction, and risk factor modification leads to improvement in vascular function.
Journal ArticleDOI
Cardiac Troponin T Measured by a Highly Sensitive Assay Predicts Coronary Heart Disease, Heart Failure, and Mortality in the Atherosclerosis Risk in Communities Study
Justin T. Saunders,Justin T. Saunders,Vijay Nambi,James A. de Lemos,Lloyd E. Chambless,Salim S. Virani,Salim S. Virani,Eric Boerwinkle,Ron C. Hoogeveen,Xiaoxi Liu,Brad C. Astor,Thomas H. Mosley,Aaron R. Folsom,Gerardo Heiss,Josef Coresh,Christie M. Ballantyne +15 more
TL;DR: In this paper, the authors evaluated whether cardiac troponin T (cTnT) measured with a new highly sensitive assay was associated with incident coronary heart disease (CHD), mortality, and hospitalization for heart failure (HF) in a general population of participants in the ARIC Study.
Journal ArticleDOI
Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study.
Carl J. Pepine,R. David Anderson,Barry L. Sharaf,Steven E. Reis,Karen M. Smith,Eileen M. Handberg,B. Delia Johnson,George Sopko,C. Noel Bairey Merz +8 more
TL;DR: In this article, the authors investigated whether coronary microvascular dysfunction predicts major adverse outcomes during follow-up among women with signs and symptoms of ischemia, and they found significant associations between CFR and major adverse events (death, nonfatal myocardial infarction, non-fatal stroke, or hospital stay for heart failure).
Journal ArticleDOI
Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve.
Bernhard A. Herzog,Lars Husmann,Ines Valenta,Oliver Gaemperli,Patrick T. Siegrist,Fabian M. Tay,Nina Burkhard,Christophe A. Wyss,Philipp A. Kaufmann +8 more
TL;DR: Perfusion findings in (13)N-ammonia PET and CFR are strong outcome predictors, suggesting a "warranty" period of 3 years if normal CFR is associated with normal perfusion and Conversely, in patients with abnormal perfusion, an impaired CFR has added value for predicting adverse outcomes.
References
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Optimal Medical Therapy with or without PCI for Stable Coronary Disease
William E. Boden,Koon K. Teo,Pamela M. Hartigan,David J. Maron,William J. Kostuk,Merril L. Knudtson,Marcin Dada,Paul Casperson,Crystal L. Harris,Bernard R. Chaitman,Leslee J. Shaw,Gilbert Gosselin,Shah Nawaz,Lawrence M. Title,Gerald T. Gau,Alvin Blaustein,David C. Booth,Eric R. Bates,John A. Spertus,Daniel S. Berman,William S. Weintraub +20 more
TL;DR: As an initial management strategy in patients with stable coronary artery disease, PCI did not reduce the risk of death, myocardial infarction, or other major cardiovascular events when added to optimal medical therapy.
Journal ArticleDOI
Diabetes and Cardiovascular Disease: The Framingham Study
TL;DR: After adjustment for other associated risk factors, the relative impact of diabetes on CHD, IC, or stroke incidence was the same for women as for men; for CVD death and CHF, it was greater for women.
Journal ArticleDOI
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction: Comorbidities Drive Myocardial Dysfunction and Remodeling Through Coronary Microvascular Endothelial Inflammation
Walter Paulus,Carsten Tschöpe +1 more
TL;DR: In this article, a new paradigm for heart failure with preserved ejection fraction (HFPEF) development is proposed, which identifies a systemic proinflammatory state induced by comorbidities as the cause of myocardial structural and functional alterations.
Journal ArticleDOI
Diabetes and cardiovascular disease: The Framingham study
TL;DR: For each of the cardiovascular diseases (CVD), morbidity and mortality were higher for diabetic women than for nondiabetic men and for CVD death and CHF, it was greater for women.
Journal ArticleDOI
The “No-Reflow” Phenomenon after Temporary Coronary Occlusion in the Dog
TL;DR: Results suggest that 40 minutes of ischemia were tolerated by the capillary bed of the dog heart without serious capillary damage or perfusion defects, but that 90 min of ischemic injury was associated with the "no-reflow" phenomenon, i.e., failure to achieve uniform reperfusion.