Isolation and characterization of an isolate (HN) of Marek's disease virus with low pathogenicity.
B. R. Cho,S. G. Kenzy +1 more
TLDR
A cytopathic agent was isolated and characterized as an isolate of Marek's disease herpesvirus (MDHV) with low pathogenicity, and referred to as the HN isolate, which did not cause clinical MareK's disease (MD) or death in a highly susceptible line of chickens within 5 weeks after exposure.Abstract:
A cytopathic agent was isolated and characterized as an isolate of Marek's disease herpesvirus (MDHV) with low pathogenicity, and referred to as the HN isolate. This isolate of MDHV did not cause clinical Marek's disease (MD) or death in a highly susceptible line of chickens within 5 weeks after exposure. Gross lesions of limited extent were noted in a few of the inoculated birds. Microscopic nerve lesions in the inoculated and contact-infected birds were invariably minimal, closely resembling C-type MD lesions.read more
Citations
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Journal ArticleDOI
Characteristics of Marek's disease viruses isolated from vaccinated commercial chicken flocks: association of viral pathotype with lymphoma frequency.
TL;DR: The vvMDVs were obtained from both broiler and layer flocks in five widely separated states but may only recently have become prevalent, since none were represented among 10 MDV isolates obtained before 1975, suggesting that npMDVs may augment turkey-herpesvirus-induced vaccinal immunity.
Book ChapterDOI
Protective efficacy of Marek's disease vaccines.
TL;DR: In the United States, losses from the condemnation at slaughter of young broiler chickens with visible lesions of Marek’s disease have decreased from 1.5% in 1970 to 0.0121% in 1999, a reduction of over 99% (Fig. 1).
Journal ArticleDOI
Monoclonal antibody-mediated immunoprecipitation of proteins from cell, infected with marek's disease virus or turkey herpesvirus
Robert F. Silva,Lucy F. Lee +1 more
TL;DR: Competition immunoprecipitation and peptide mapping by limited proteolysis confirmed that the three glycoproteins and the 79,000-Da protein contain MDV-HVT common epitopes.
Journal ArticleDOI
New serotype 2 and attenuated serotype 1 Marek's disease vaccine viruses: comparative efficacy.
TL;DR: Four new monovalent and polyvalent vaccines based on these two isolates protected chickens better than FC126 alone or CV1988/C alone, and three of these new vaccines provided better protection than the bivalent (FC126 + SB-1) vaccine.
Journal ArticleDOI
Field trials to test the efficacy of polyvalent Marek's disease vaccines in broilers
TL;DR: In all four trials, chickens receiving polyvalent vaccines had lower leukosis (MD) condemnation rates than chickens vaccinated with HVT alone; when data was summarized for each vaccine type in each trial, condemnation rates for the bivalent- or trivalent-vaccinated groups were 56-96% (mean 78%) lower than those for HVT- vaccinated chickens.
References
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Journal ArticleDOI
Characterization of five isolates of Marek's disease.
H.G. Purchase,P.M. Biggs +1 more
TL;DR: March’s disease can be readily transmitted from field outbreaks to Houghton Poultry Research Station (HPRS) Rhode Island Red and Brown Leghorn chickens and females were more susceptible to MD than were males.
Journal ArticleDOI
Cell culture techniques for primary isolation of Marek's disease-associated herpesvirus.
Journal ArticleDOI
Studies on acute Marek's disease. I. Characteristics of isolate GA in chickens.
Eidson Cs,Schmittle Sc +1 more
TL;DR: The present study was done to report on an MD isolate found in Georgia and discuss the pathogenic aspects of this agent, ascertain the optimum age for obtaining plasma from birds experimentally infected with isolate GA, and compare MD in birds injected with plasma or tumor suspension for a series of 9 passages at bi-weekly intervals.
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