Kinetic Studies of the Formation of Number of Spiropyrrolidine
TLDR
The rate of reaction between Schiff bases (N-Benzylidene-4-Picolyamine) and its derivatives with Chalcone(2-benzylidine-1-tetralone) to form spiropyrrolidine have been studied in this article.Abstract:
The rate of reaction between Schiff bases (N-Benzylidene-4-Picolyamine) and its derivatives with Chalcone(2-benzylidine-1-tetralone) to form spiropyrrolidine have been studied in DMF. This study occurred in two steps: The first step involved following the formation of intermediate by Fluorescence. The study indicated a pseudo first order dependence with rates 3,4-Dimethoxy> p-OCH3 > p-CH3 > H > P-Cl > P-NO2 at any temperature (298-318 K). The effect of substituents on the rate showed that electronic factors, inductive, conjugative and steric factors play reasonable role on the stability of the intermediates. The second step involved the disappearance of intermediate (cyclization process) to form the final product (spiropyrrolidine). This step was followed by UV technique and indicated a first order dependence with rates P-NO2 > p-Cl > H > p-CH3 > pOCH3 > 3,4-Dimethoxy. A suitable mechanism for this type of reaction, which is consistent with the results, has been postulated.read more
Citations
More filters
The Conservation of Orbital Symmetry (福井謙一とフロンティア軌導理論) -- (参考論文)
TL;DR: In this article, the most basic ideas of molecular orbital theory-the concepts of symmetry, overlap, interaction, bonding, and the nodal structure of wave functions are used to rationalize and predict the stereochemical course of virtually every concerted organic reaction.
Journal ArticleDOI
Kinetics Study of the Formation of Pyrmidine Thione from the Reaction of 2,6-dibenzylidinecyclohexanone and its Derivatives with Thiourea
TL;DR: In this article, the authors studied the reaction of thiourea to 2,6-dibenzylidenecyclohexanone and its derivatives and found that the reaction is a pseudo-first order process, which includes a nucleophilic attack by thIourea at the carbonyl group of the ketone system to produce the heterocyclic pyrimidine thione "thiopyrimidine" (Claisen route mechanism).
References
More filters
BookDOI
Organic synthesis in water
TL;DR: Aqueous transition metal catalyzed carbon-carbon bond pairing reactions in aqueous medium were studied in this paper, where base-catalyzed Aldol-and Michael-type condensations were used.