Book ChapterDOI
Liver Fibrosis Assessment Using Transient Elastography Guided with Real-Time B-Mode Ultrasound Imaging
Yongping Zheng,Tak Man Mak,Zhengming (黃錚銘) Huang,Chung Wai James Cheung,Yong Jin Zhou,Jun Feng He +5 more
- pp 1036-1039
TLDR
A transient ultrasound elastography system with real-time B-mode imaging for the assessment of liver fibrosis and the results were compared with those measured by Fibroscan.Abstract:
Liver fibrosis is a kind of chronic damage of the liver The progression of liver fibrosis will result cirrhosis which is one of the top 10 causes of death in the western world Recently, a device developed based on transient ultrasound elastography, named as Fibroscan, shows promising results with high accuracy and good reproducibility However, this device does not provide visual guidance for the liver being tested during measurement We aim to design and validate a transient elastography system with real-time B-mode imaging for liver fibrosis assessment Our development is based on a conventional B-mode ultrasound scanner, which consists of a B-mode ultrasound probe fixed along the axis of a mechanical vibrator The induced shear wave propagates through the liver tissue During measurement, B-mode ultrasound imaging with a frame rate of 30 f/s is generated in real-time to view the morphological information of the tissue, and an A-mode ultrasound with a frame rate of 6000 f/s is generated to track the propagation of shear wave at a selected location The propagation speed of the shear wave is related to the tissue stiffness and Young’s modulus is calculated The system was tested using a series of custom-made phantoms with different stiffness and the results were compared with those measured by Fibroscan For phantom A1, the Young’s modulus is 324 kPa and 354 kPa obtained by Fibroscan and our system, respectively For phantom A2, the modulus is 159 kPa and 198 kPa, respectively For the preliminary in vivo assessment, the Young’s modulus of a normal male subject is 58 kPa and 75 kPa obtained by Fibroscan and our system, respectively In summary, we have successfully developed a transient ultrasound elastography system with real-time B-mode imaging for the assessment of liver fibrosisread more
Citations
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Journal ArticleDOI
Liver Fibrosis Assessment Using Transient Elastography Guided with Real-Time B-mode Ultrasound Imaging: A Feasibility Study
TL;DR: It is demonstrated that Liverscan with a specifically designed probe was able to measure and differentiate liver of different stiffness using the established measurement protocol under the guidance of real-time B-mode ultrasound imaging.
Journal ArticleDOI
Endocrine Tumor Classification via Machine-Learning-Based Elastography: A Systematic Scoping Review
Ye-Jiao Mao,Li-Wen Zha,Andy Yiu-Chau Tam,Hyo-Jung Lim,A. K. Cheung,Ying-Qi Zhang,Ming Ni,James Chung Wai Cheung,Duo Wai-Chi Wong +8 more
TL;DR: In this paper , the authors focused on the applications and performance of machine-learning-based elastography in classifying endocrine tumors, which can further improve diagnostic accuracy and reliability.
References
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Transient elastography: a new noninvasive method for assessment of hepatic fibrosis
Laurent Sandrin,Bertrand Fourquet,Jean-Michel Hasquenoph,Sylvain Yon,Céline Fournier,F. Mal,Christos Christidis,Marianne Ziol,Bruno Poulet,Farad Kazemi,Michel Beaugrand,Robert Palau +11 more
TL;DR: Liver elasticity measurements were reproducible, operator-independent and well correlated and the intra- and interoperator reproducibility of the technique, as well as its ability to quantify liver fibrosis, were evaluated in 106 patients with chronic hepatitis C.
Journal ArticleDOI
Magnetic resonance elastography by direct visualization of propagating acoustic strain waves
Raja Muthupillai,D. J. Lomas,Phillip J. Rossman,James F. Greenleaf,Armando Manduca,Richard L. Ehman +5 more
TL;DR: The results indicate that displacement patterns corresponding to cyclic displacements smaller than 200 nanometers can be measured and suggest the feasibility of a medical imaging technique for delineating elasticity and other mechanical properties of tissue.
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Intraobserver and Interobserver Variations in Liver Biopsy Interpretation in Patients with Chronic Hepatitis C
TL;DR: It is revealed that certain features of major importance in assessing disease activity show significant observer variation, including the acceptable degree of concordance of the Knodell index, whereas other numerical items displayed substantial observer variations.
Journal ArticleDOI
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
Arie Regev,Mariana Berho,Lennox J. Jeffers,Clara Milikowski,Enrique Molina,Nikolaos Pyrsopoulos,Zheng Zhou Feng,K. Rajender Reddy,Eugene R. Schiff +8 more
TL;DR: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection is found to be low and consistent with previous studies.
Journal ArticleDOI
Liver fibrosis – from bench to bedside
TL;DR: Current knowledge about the nature and prognosis of fibrosis in different forms of chronic liver disease with recent advances in elucidating its pathophysiology form the basis for rational treatment of hepatic fibrosis, which are summarized.