Journal ArticleDOI
Long-term Consequences of Kawasaki Disease A 10- to 21-Year Follow-up Study of 594 Patients
Hirohisa Kato,Tetsu Sugimura,Teiji Akagi,Noboru Sato,Kanoko Hashino,Yasuki Maeno,Takeyo Kazue,Genzyu Eto,Rumi Yamakawa +8 more
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TLDR
The incidence of coronary aneurysm in acute Kawasaki disease was 25%, 55% of which showed regression, and during follow-up, ischemic heart disease developed in 4.7% and myocardial infarction in 1.9%.Abstract:
Background The long-term consequences of the cardiovascular sequelae in Kawasaki disease remain uncertain. Methods and results We identified 594 consecutive children with acute Kawasaki disease between 1973 and 1983, and this cohort was followed up for 10 to 21 years (mean, 13.6 years). In all patients, we evaluated coronary lesions by coronary angiography just after the acute stage. One hundred and forty-six patients (24.6%) were diagnosed as having coronary aneurysms. A second angiogram was performed 1 to 2 years later in all 146 patients who previously had coronary aneurysms, which demonstrated that 72 (49.3%) of these 146 had regression in the coronary aneurysm. A third angiogram was performed for 62 patients, a fourth for 29, and a fifth for 17. By 10 to 21 years after the onset of the illness, stenosis in the coronary aneurysm had developed in 28 patients. Myocardial infarction occurred in 11 patients, 5 of whom died. In the 26 patients with giant coronary aneurysms, stenotic lesions developed in 12, and no regression occurred. The 448 patients with normal findings at the first angiogram subsequently never developed any abnormal cardiac findings. Systemic artery aneurysms developed in 13 patients (2.2%), and valvular heart disease appeared in 7 (1.2%). Conclusions The incidence of coronary aneurysm in acute Kawasaki disease was 25%, 55% of which showed regression. During follow-up, ischemic heart disease developed in 4.7% and myocardial infarction in 1.9%. Death occurred in 0.8%.read more
Citations
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Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association.
Brian W. McCrindle,Anne H. Rowley,Jane W. Newburger,Jane C. Burns,Anne F. Bolger,Michael H. Gewitz,Annette L. Baker,Mary Anne Jackson,Masato Takahashi,Pinak B. Shah,Tohru Kobayashi,Mei-Hwan Wu,Tsutomu Saji,Elfriede Pahl +13 more
TL;DR: These recommendations provide updated and best evidence-based guidance to healthcare providers who diagnose and manage Kawasaki disease, but clinical decision making should be individualized to specific patient circumstances.
Journal ArticleDOI
ACC/AHA 2008 guidelines for the management of adults with congenital heart disease: Executive summary - A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (writing committee to develop guidelines for the management of adults with congenital heart disease)
Carole A. Warnes,Roberta G. Williams,Thomas M. Bashore,John S. Child,Heidi M. Connolly,Joseph A. Dearani,Pedro J. del Nido,James W. Fasules,Thomas P. Graham,Ziyad M. Hijazi,Sharon A. Hunt,Mary Etta King,Michael J. Landzberg,Pamela D. Miner,Martha J. Radford,Edward P. Walsh,Gary D. Webb +16 more
TL;DR: In this paper, the use of diagnostic procedures and therapies introduced and tested for detection, management, or prevention of disease is discussed. But, the focus is on the medical profession.
Journal ArticleDOI
Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease A Statement for Health Professionals From the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association
Jane W. Newburger,Masato Takahashi,Michael A. Gerber,Michael H. Gewitz,Lloyd Y. Tani,Jane C. Burns,Stanford T. Shulman,Ann F. Bolger,Patricia Ferrieri,Robert S. Baltimore,Walter R. Wilson,Larry M. Baddour,Matthew E. Levison,Thomas J. Pallasch,Donald A. Falace,Kathryn A. Taubert +15 more
TL;DR: Recommendations for the initial evaluation, treatment in the acute phase, and long-term management of patients with Kawasaki disease are intended to assist physicians in understanding the range of acceptable approaches for caring for patients withawasaki disease.
Journal ArticleDOI
An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study.
Lucio Verdoni,Angelo Mazza,Annalisa Gervasoni,Laura Martelli,Maurizio Ruggeri,Matteo Ciuffreda,Ezio Bonanomi,Lorenzo D'Antiga +7 more
TL;DR: Children diagnosed after the SARS-CoV-2 epidemic began showed evidence of immune response to the virus, were older, had a higher rate of cardiac involvement, and features of MAS, and a similar outbreak of Kawasaki-like disease is expected in countries involved in the SEMS epidemic.
Journal ArticleDOI
Diagnosis, treatment, and long-term management of Kawasaki disease: A statement for health professionals from the committee on rheumatic fever, endocarditis, and Kawasaki disease, council on cardiovascular disease in the young, American Heart Association
Jane W. Newburger,Masato Takahashi,Michael A. Gerber,Michael H. Gewitz,Lloyd Y. Tani,Jane C. Burns,Stanford T. Shulman,Ann F. Bolger,Patricia Ferrieri,Robert S. Baltimore,Walter R. Wilson,Larry M. Baddour,Matthew E. Levison,Thomas J. Pallasch,Donald A. Falace,Kathryn A. Taubert +15 more
TL;DR: A new algorithm is proposed to aid clinicians in deciding which children with fever for ≥5 days and ≤4 classic criteria should undergo electrocardiography, receive intravenous gamma globulin (IVIG) treatment, or both for Kawasaki disease.
References
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A New Infantile Acute Febrile Mucocutaneous Lymph Node Syndrome (MLNS) Prevailing in Japan
TL;DR: Recently, rickettsia-like bodies were found by electron microscopy in biopsy specimens from the skin and lymph nodes of the patients, leading us to believe that this clinical picture is a new clinical entity.
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Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children
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A Single Intravenous Infusion of Gamma Globulin as Compared with Four Infusions in the Treatment of Acute Kawasaki Syndrome
Jane W. Newburger,Masato Takahashi,Alexa S. Beiser,Jane C. Burns,John F. Bastian,K J Chung,Steven D. Colan,C E Duffy,David Fulton,Mary P. Glode +9 more
TL;DR: In children with acute Kawasaki disease, a single large dose of intravenous gamma globulin is more effective than the conventional regimen of four smaller daily doses and is equally safe.
Journal ArticleDOI
High-dose intravenous gammaglobulin for Kawasaki disease.
Kenshi Furusho,Katsuko Sato,Takeshi Soeda,Hiroshi Matsumoto,Takahiro Okabe,Tsuneo Hirota,Shinya Kawada +6 more
TL;DR: High-dose IVGG seems to reduce the frequency of coronary artery abnormalities in patients with Kawasaki disease, and this lesion was confirmed in 1 of the 6 cases in the IVGG group and in 11 of the 19 controls.