Journal ArticleDOI
Malignant pleural mesothelioma: value of CT and MR imaging in predicting resectability.
Edward F. Patz,Kitt Shaffer,D R Piwnica-Worms,Maxine S. Jochelson,M. Sarin,David J. Sugarbaker,Robert D. Pugatch +6 more
TLDR
CT and MR provided similar information on resectability in most cases, and CT is more widely available and used than MR as the initial study when determining resectabilities.Abstract:
Our objective was to determine if CT or MR imaging findings could be used to accurately predict resectability in patients with biopsy-proved malignant pleural mesotheliomas.CT and MR findings in 41 consecutive patients with malignant mesotheliomas who were referred to the thoracic surgery clinic for extrapleural pneumonectomy were studied by thoracic radiologists before surgery. Review of radiologic studies focused on local invasion of three separate regions: the diaphragm, chest wall, and mediastinum. Results of all imaging examinations were carefully correlated with intraoperative, gross, and microscopic pathologic findings.After radiologic and clinical evaluation, 34 patients (83%) had thoracotomy; 24 of these had tumors that were resectable. The sensitivity was high (> 90%) for both CT and MR in each region. Specificity, however, was low, probably because of the small number of patients with unresectable tumors.CT and MR provided similar information on resectability in most cases. Sensitivity was high...read more
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Journal ArticleDOI
Management of malignant pleural effusions.
Veena B. Antony,Robert Loddenkemper,P. Astoul,C. Boutin,P. Goldstraw,Jeffery W. Hott,F. Rodriguez Panadero,Steven A. Sahn +7 more
TL;DR: Post mortem studies suggest that most pleural metastases arise from tumour emboli to the visceral pleural surface, with secondary seeding to the parietal pleura 1, 20, and other possible mechanisms include direct tumour invasion (in lung cancers, chest wall neoplasms, and breast carcinoma), haematogenous spread to parietal Pleura, and lymphatic involvement.
Journal ArticleDOI
Malignant pleural mesothelioma: evaluation with CT, MR imaging, and PET.
Zhen J. Wang,Gautham P. Reddy,Michael B. Gotway,Charles B. Higgins,David M. Jablons,Mohan R. Ramaswamy,Randall A. Hawkins,W. Richard Webb +7 more
TL;DR: In this paper, the authors used positron emission tomography (PET) for the diagnosis and staging of malignant pleural mesothelioma (MPM) and found that PET can provide anatomic and metabolic information, especially in cases of extrathoracic and mediastinal nodal metastasis.
Journal ArticleDOI
Metabolic Imaging of Malignant Pleural Mesothelioma With Fluorodeoxyglucose Positron Emission Tomography
Francois Benard,Daniel H. Sterman,Robin J. Smith,Larry R. Kaiser,Steven M. Albelda,Abass Alavi +5 more
TL;DR: FDG-PET imaging was a sensitive method to identify malignant mesothelioma and determine the extent of the disease process in this highly selected population of patients.
Journal ArticleDOI
Extrapleural pneumonectomy in the multimodality therapy of malignant pleural mesothelioma. Results in 120 consecutive patients.
David J. Sugarbaker,Jose Manuel Perez Garcia,William G. Richards,David H. Harpole,Elizabeth Healy-Baldini,Malcolm M. DeCamp,Steven J. Mentzer,Michael J. Liptay,Gary M. Strauss,Scott J. Swanson +9 more
TL;DR: Extrapleural pneumonectomy with adjuvant therapy is appropriate treatment for selected patients with malignant mesothelioma selected using a revised staging system.
Journal ArticleDOI
Node status has prognostic significance in the multimodality therapy of diffuse, malignant mesothelioma
David J. Sugarbaker,Gary M. Strauss,Thomas J. Lynch,William G. Richards,Steven J. Mentzer,T H Lee,Joseph M. Corson,Karen H. Antman +7 more
TL;DR: Data provide a rationale for a revised staging system for malignant pleural mesothelioma and permit stratification of patients into groups likely to benefit from aggressive multimodality treatment.
References
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Journal ArticleDOI
Farmer's lung. Long-term outcome and lack of predictive value of bronchoalveolar lavage fibrosing factors.
Marc Lalancette,Guy Carrier,Michel Laviolette,Sylvie Ferland,Jean Rodrique,Raymond Bégin,André M. Cantin,Yvon Cormier +7 more
TL;DR: It is concluded that airflow obstruction with or without emphysema is an important long-term sequela of FL and that bronchoalveolar lavage fluid markers or substrates of fibrosis do not predict outcome in this disease.