Maternal and fetal levels of propofol at caesarean section.
Reads0
Chats0
TLDR
Apgar scores were higher with shorter incision to delivery times but were not correlated to umbilical levels of propofol, and distribution of prop ofol is rapid across the placenta and in the fetus.Abstract:
Twenty women were given a bolus induction of propofol 2.0 mg.kg-1 for elective caesarean section. Induction to delivery times ranged from five to fourteen minutes. At delivery the maternal venous (MV) concentrations of propofol ranged from 0.53 to 1.48 micrograms.ml-1 umbilical vein (UV) 0.39 to 1.4 micrograms.ml-1 and umbilical artery (UA) 0.34 to 0.68 micrograms.ml-1 MV propofol concentrations were always higher than corresponding UV concentrations. The mean (95% confidence interval) UV/MV ratio was 0.65 (0.56-0.74) and the mean UA/UV ratio was 1.07 (0.99-1.15). Neither ratio was shown to be correlated with induction to delivery time. Distribution of propofol is rapid across the placenta and in the fetus. Apgar scores were higher with shorter incision to delivery times but were not correlated to umbilical levels of propofol.read more
Citations
More filters
Journal ArticleDOI
Propofol. An update of its use in anaesthesia and conscious sedation.
TL;DR: Accumulating clinical experience in cardiac and neurosurgery suggests that the full potential of propofol has yet to be realised, and the relative benefits of prop ofol compared with the newer volatile agents (desflurane and sevoflurane) and Propofol/volatile agent combinations need to be examined in this clinical setting.
Journal ArticleDOI
Update on bispectral index monitoring.
TL;DR: BIS technology is moving out of the operating room and into diverse environments where conscious and deep sedation are provided, and anesthesiologists need to be actively involved in promoting patient safety and helping transition this technology into broader use.
Journal ArticleDOI
Daily and seasonal variation in response to stress in captive starlings (Sturnus vulgaris): corticosterone.
TL;DR: Although stress- induced glucose levels showed no circadiel rhythm, the stress-induced elevation of glucose above baseline showed a significant daily rhythm, indicating that stress elevated plasma glucose levels only during the scotophase in all three seasons.
Journal ArticleDOI
Effect of Nitrous Oxide on Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures
Steven Mennerick,Vesna Jevtovic-Todorovic,Slobodan M. Todorovic,Weixing Shen,John W. Olney,Charles F. Zorumski +5 more
TL;DR: It is found that N2O inhibits both NMDA and non-NMDA receptor-mediated responses to exogenous agonist, and the effects of N2o on synaptic transmission are confined to postsynaptic targets.
Journal ArticleDOI
Recovery of Cognitive Function After Remifentanil-Propofol Anesthesia: A Comparison with Desflurane and Sevoflurane Anesthesia
TL;DR: Emergence and return of cognitive function was significantly faster after remifentanil-propofol compared with desflurane and sevoflurane up to 60 min after anesthesia administration, and awakening and intermediate recovery times were significantly faster.
References
More filters
Journal ArticleDOI
Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia.
TL;DR: This clinical study demonstrates the feasibility of performing pharmacokinetic and pharmacodynamic analyses when complex infusion and bolus regimens are used for administering iv anesthetics.
Journal ArticleDOI
Improved method for the determination of propofol in blood by high-performance liquid chromatography with fluorescence detection.
Journal ArticleDOI
Principles of Drug Biodisposition in the Neonate
James B. Besunder,James B. Besunder,Michael D. Reed,Michael D. Reed,Jeffrey L. Blumer,Jeffrey L. Blumer +5 more
TL;DR: Recommendations for neonatal drug therapy are based upon a critical interpretation of data, an understanding of fetal development and maturational processes, and anUnderstanding of how disease states may affect drug biodisposition in the neonate.
Journal ArticleDOI
Comparision of the new emulsion formulation of propofol with methohexitone and thiopentone for induction of anaesthesia in day cases
N. Mackenzie,I.S. Grant +1 more
TL;DR: The new emulsion formulation of di-isopropyl phenol (propofol) was compared with methohexitone and thiopentone for induction of anaesthesia in day cases and post-anaesthetic recovery was superior with propofol, with virtual absence of side effects and rapid recovery with little impairment of psychomotor function 30 min after anaesthesia.
Journal ArticleDOI
Neonatal Effect of Prolonged Anesthetic Induction for Cesarean Section
TL;DR: The relationship of induction-to-delivery and uterine incision-todelivery intervals to neonatal outcome was studied in 105 parturient women undergoing cesarean section as discussed by the authors.