Journal ArticleDOI
Maternal high-dose valacyclovir and its correlation with newborn blood viral load and outcome in congenital cytomegalovirus infection
Anna Goncé,Ameth Hawkins-Villarreal,Ameth Hawkins-Villarreal,Laura Salazar,L. Guirado,Maria-Angeles Marcos,Jara Pascual Mancho,Pilar Prats,Marta López,Elisenda Eixarch,Maria-Dolors Salvia,Claudia Fortuny,Francesc Figueras +12 more
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TLDR
Fetal CMV lesions remained stable with high-dose maternal valacyclovir and newborn viral load was unchanged despite treatment duration and fetal/neonatal abnormalities.Abstract:
Currently, there is no validated treatment for fetal cytomegalovirus (CMV). Two studies suggest that high-dose maternal valacyclovir decreases fetal viral load and improves outcomes in moderately-s...read more
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Effectiveness and safety of prenatal valacyclovir for congenital cytomegalovirus infection: systematic review and meta‐analysis
TL;DR: In this article , the safety and effectiveness of prenatal valacyclovir therapy in pregnancies with maternal cytomegalovirus (CMV) infection was investigated, and the main aim of this systematic review and meta-analysis was to investigate the safety, effectiveness and risk of pregnancy with maternal CMV infection.
Journal ArticleDOI
High‐dose valacyclovir to prevent congenital cytomegalovirus transmission in pregnancy: is it possible to reduce major side effects?
TL;DR: In this article , a systematic review and meta-analysis was conducted to evaluate the efficacy of valacyclovir (VCV) in preventing vertical infection in CMV-positive pregnant women.
Journal ArticleDOI
Cytomegalovirus seronegativity rate in pregnant women and primary cytomegalovirus infection during pregnancy in rural Germany
TL;DR: In this article , the authors determined the seroprevalence rate for cytomegalovirus in pregnant women and the rate of CMV serological testing utilised during pregnancy in a rural region in Germany.
References
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Journal ArticleDOI
Review and meta‐analysis of the epidemiology of congenital cytomegalovirus (CMV) infection
TL;DR: CMV is a common congenital infection worldwide that can lead to permanent disabilities and there is an urgent need for interventions that can reduce the substantial burden of this often overlooked disease.
Journal ArticleDOI
Congenital Cytomegalovirus Infection: Association between Virus Burden in Infancy and Hearing Loss
Suresh B. Boppana,Karen B. Fowler,Robert F. Pass,Lisa B. Rivera,Russell D. Bradford,Fred D. Lakeman,William J. Britt +6 more
TL;DR: In children with asymptomatic congenital CMV infection, hearing loss was associated with increased amounts of urine CMV and PB CMV DNA during early infancy, and children with normal hearing were at a lower risk for hearing loss.
Journal ArticleDOI
Neonatal Cytomegalovirus Blood Load and Risk of Sequelae in Symptomatic and Asymptomatic Congenitally Infected Newborns
Marcello Lanari,Tiziana Lazzarotto,Valentina Venturi,Irene Papa,Liliana Gabrielli,Brunella Guerra,Maria Paola Landini,Giacomo Faldella +7 more
TL;DR: As an independent predictive factor of outcome, neonatal viremia is another useful element for neonatal counseling and therapeutic choices in symptomatic and asymptomatic newborns with CMV congenital infection.
Journal ArticleDOI
Maternal administration of valaciclovir in symptomatic intrauterine cytomegalovirus infection.
Jacquemard F,M. Yamamoto,Jean-Marc Costa,S. Romand,Jaqz-Aigrain E,A. Dejean,F. Daffos,Yves Ville +7 more
TL;DR: Early experience with treatment of intrauterine cytomegalovirus infection using maternal oral administration of valaciclovir (VACV) is reported using maternal Oral Administration of VACV.
Journal ArticleDOI
In utero treatment of congenital cytomegalovirus infection with valacyclovir in a multicenter, open-label, phase II study
Marianne Leruez-Ville,Marianne Leruez-Ville,Idir Ghout,Laurence Bussières,Laurence Bussières,Julien Stirnemann,Julien Stirnemann,Jean-François Magny,Jean-François Magny,Sophie Couderc,Laurent Salomon,Laurent Salomon,Tiffany Guilleminot,Tiffany Guilleminot,Philippe Aegerter,Guillaume Benoist,Norbert Winer,Olivier Picone,François Jacquemard,Yves Ville,Yves Ville +20 more
TL;DR: In this article, the authors evaluated the efficacy of oral valacyclovir, 8 g daily, for pregnant women carrying a symptomatic cytomegalovirus-infected fetus, targeting a high risk group for developing both neurosensory and neurological impairment.