Fred D. Lakeman

TL;DR: HSV DNA was detected by polymerase chain reaction (PCR) in CSF of 53 (98%) of 54 patients with biopsy-proven HSE and was detected in all 18 CSF specimens obtained before brain biopsy from patients with proven HSE.

TL;DR: An open-label evaluation of intravenous acyclovir at dosages higher than the 30 mg/kg/d standard dosage approved by the US Food and Drug Administration indicated that the survival rate for patients treated with HD acy Clovir was statistically significantly higher than for patientstreated with SD acyClovir.

TL;DR: Comparisons between patients treated in the periods between 1981-1988 and 1989-1997 according to extent of disease revealed that the mean time between the onset of disease symptoms and initiation of therapy has not changed significantly from the early 1980s to the late 1990s, demonstrating that no progress has been made in decreasing the interval between onset of HSV symptoms and initiated antiviral therapy.

TL;DR: This review summarizes the current knowledge on the pathogenesis, diagnosis, and treatment of herpes simplex virus infections of the brain.

TL;DR: For neonates with CNS or disseminated infection, disease duration and frequency of prematurity were significantly decreased in the second period, as was the frequency of skin vesicles for newborns with SEM or dissemination infection.