Mechanisms and stereochemistry in fatty acid metabolism.
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This article is published in Biochemical Journal.The article was published on 1970-08-01 and is currently open access. It has received 82 citations till now. The article focuses on the topics: Fatty acid metabolism.read more
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Geometric and Electronic Structure/Function Correlations in Non-Heme Iron Enzymes
Edward I. Solomon,Thomas C. Brunold,Mindy I. Davis,Jyllian N. Kemsley,Sang-Kyu Lee,Nicolai Lehnert,Frank Neese,Andrew J. Skulan,Yi-Shan Yang,Jing Zhou +9 more
TL;DR: A detailed molecular mechanism has been proposed for IPNS based on spectroscopic and crystallographic studies and the role of cosubstrate ascorbate is proposed to reduce the toxic peroxo byproduct to water.
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Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase
TL;DR: Observations suggest that the membrane fatty acid desaturases and hydrocarbon hydroxylases have a related protein fold, possibly arising from a common ancestral origin.
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Lipids of aquatic organisms as potential contributors to lacustrine sediments—II☆
TL;DR: The relationship between the lipid composition of organisms in the water column of an eutrophic lake and the lipid compositions of underlying sediments, previously examined for n-alkanols and steroids, is now reported for hydrocarbons, ketones and carboxylic acids.
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Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid.
TL;DR: Inhibition and analog studies suggest that the methylene chain of stearyl-CoA assumes an eclipsed ("gauche") conformation at carbon atoms 9,10 in the enzyme-substrate complex of desaturase, and isotope rate effects obtained with deuterated st earyl- CoA derivatives indicate that hydrogen removal is the rate-limiting step of desaturation.
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The oxidative desaturation of unsaturated fatty acids in animals
TL;DR: The 6-desaturation of fatty acids would be the principal regulatory step in the biosynthesis of polyunsaturated fatty acids in rat microsomes.