Mechanisms regulating melanogenesis
Reads0
Chats0
TLDR
The identification and comprehension of the melanogenesis mechanism facilitate the understanding of the pathogenesis of pigmentation disorders and the development of potential therapeutic options.Abstract:
Skin pigmentation is an important human phenotypic trait whose regulation, in spite of recent advances, has not yet been fully understood. The pigment melanin is produced in melanosomes by melanocytes in a complex process called melanogenesis. The melanocyte interacts with endocrine, immune, inflammatory and central nervous systems, and its activity is also regulated by extrinsic factors such as ultraviolet radiation and drugs. We have carried out a review of the current understanding of intrinsic and extrinsic factors regulating skin pigmentation, the melanogenesis stages and related gene defects. We focused on melanocyte-keratinocyte interaction, activation of melanocortin type 1 receptor (MC1-R) by peptides (melanocyte-stimulating hormone and adrenocorticotropic hormone) resulting from proopiomelanocortin (POMC) cleavage, and mechanisms of ultraviolet-induced skin pigmentation. The identification and comprehension of the melanogenesis mechanism facilitate the understanding of the pathogenesis of pigmentation disorders and the development of potential therapeutic options.read more
Citations
More filters
科研数据共享的挑战 (The Conundrum of Sharing Research Data)
TL;DR: Four rationales for sharing data are examined, drawing examples from the sciences, social sciences, and humanities: to reproduce or to verify research, to make results of publicly funded research available to the public, to enable others to ask new questions of extant data, and to advance the state of research and innovation.
Journal ArticleDOI
The conundrum of sharing research data
TL;DR: In this article, the authors examined four rationales for sharing data, drawing examples from the sciences, social sciences, and humanities: (1) to reproduce or to verify research, (2) to make results of publicly funded research available to the public, (3) to enable others to ask new questions of extant data, and (4) to advance the state of research and innovation.
Journal ArticleDOI
Signaling Pathways in Melanogenesis
TL;DR: The regulatory mechanisms involved in melanogenesis are discussed and how intrinsic and extrinsic factors regulate melanin production are explained, as well as the regulatory roles of different proteins involved in pigment molecules that are endogenously synthesized by melanocytes.
Journal ArticleDOI
A systematic review of the effectiveness of interprofessional education in health professional programs
TL;DR: Student's attitudes and perceptions towards interprofessional collaboration and clinical decision-making can be potentially enhanced through interprofessional education, however, the evidence for using inter professional education to teach communication skills and clinical skills is inconclusive and requires further investigation.
Journal ArticleDOI
Anatomy of open access publishing: a study of longitudinal development and internal structure
Mikael Laakso,Bo-Christer Björk +1 more
TL;DR: OA journal publishing is disrupting the dominant subscription-based model of scientific publishing, having rapidly grown in relative annual share of published journal articles during the last decade.
References
More filters
Book
Dermatology in general medicine
TL;DR: Introduction biology and pathophysiology of skin disorders presenting in the skin and mucous membranes dermatology and internal medicine diseases due to microbial agents therapeutics paediatric and geriatric dermatology.
Book
Fitzpatrick's Dermatology In General Medicine
Lowell A. Goldsmith,Thomas B. Fitzpatrick,Stephen I. Katz,Barbara A. Gilchrest,Amy S. Paller,David J. Leffell,K Wolff +6 more
TL;DR: Widely acclaimed dermatological treatise is completely revised and updated with over forty new chapters and an entirely new section on dermatologic surgery.
Journal ArticleDOI
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
TL;DR: Melanogenesis is a highly structured system, active since early embryogenesis and capable of superselective functional regulation that may reach down to the cellular level represented by single melanocytes, and its significance extends beyond the mere assignment of a color trait.
Journal ArticleDOI
Fitzpatrick's Dermatology in General Medicine
TL;DR: This completely revised and updated edition of ‘Fitzpatrick’ has further cemented its place in the practice of Dermatology with great clarity and easily ‘digestable’ reference material.
Journal ArticleDOI
Melanocyte biology and skin pigmentation
Jennifer Y. Lin,David E. Fisher +1 more
TL;DR: Pigmentation mutants in various species are highly informative about basic genetic and developmental pathways, and provide important clues to the processes of photoprotection, cancer predisposition and even human evolution.