Armed Forces Medical College

About: Armed Forces Medical College is a education organization based out in Pune, Maharashtra, India. It is known for research contribution in the topics: Population & Medicine. The organization has 2603 authors who have published 3378 publications receiving 25510 citations. The organization is also known as: Armed Forces Medical College, Pune & AFMCP.

A draft map of the human proteome

Abstract: The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here we present a draft map of the human proteome using high-resolution Fourier-transform mass spectrometry. In-depth proteomic profiling of 30 histologically normal human samples, including 17 adult tissues, 7 fetal tissues and 6 purified primary haematopoietic cells, resulted in identification of proteins encoded by 17,294 genes accounting for approximately 84% of the total annotated protein-coding genes in humans. A unique and comprehensive strategy for proteogenomic analysis enabled us to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-coding RNAs and upstream open reading frames. This large human proteome catalogue (available as an interactive web-based resource at http://www.humanproteomemap.org) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease.

Fitzpatrick's Dermatology in General Medicine

Abstract: Medicine, it is said, is an ever-changing science. With cutting edge research and new clinical experience exponentially expanding the realms of medical science, there is a felt need to continually update our knowledge base. ‘Fitzpatrick’ has remained a highly respected textbook, a ‘Bible’ in the practice of Dermatology, Even since the first edition of this textbook was released in 1971, newer editions have been introduced earlier than the previous ones; every five years now compared to every eight years earlier; a measure of the accelerating pace of change. The new edition is different from the previous one right from the moment it is opened. The arrangement and organization of various sections and their contents have been completely rehashed. Basic sciences, which occupied a section of its own in the previous edition, are segregated into its components which are now clubbed along with their sections of relevance, bringing with it the advantage of continuity Some reshuffling, for instance, moves Kawasaki's Syndrome from the section on ‘Bacterial Diseases’ to the section on ‘Inflammatory and Vascular Disorders’. Section-end references are truncated and readers are directed to a website for the rest, thus re-appropriating premium print space for text. Along with updating of previous concepts, new chapters on Public Health in Dermatology, Complementary and Alternative Dermatology, Drug Interactions, Dermatology in Bioterrorism and Biological Warfare have been added, underscoring globally emerging newer advances in Dermatology which the new age dermatologists should be aware of. Three column text, new stand-out font, different color codes for headings and sub headings, numerous clinical and histopathological color plates, self explanatory figurative representations, graphs, flow-charts and tables make the assimilation of the vast data a cake walk. ‘At A Glance’ windows and boxes summarizing the differential diagnoses and treatment protocols give a fish-eye view of various aspects of dermatological disorders, something that is not only crisp and precise but also relevant and easy to remember. The reader gets a ready reference point with flip-book views of section name and representative thumbnail pictures on the free margins of both sides of every page. In a nutshell, this marvelous textbook replete with latest looks, is a completely revised and updated edition with great clarity and easily ‘digestable’ reference material. With this edition, ‘Fitzpatrick’ has further cemented its place in the practice of Dermatology.

Bioreduction of aucl4− ions by the fungus, verticillium sp. and surface trapping of the gold nanoparticles formed

Abstract: Fungi make piles of gold! A green-chemistry route, based on the bioreduction of AuCl 4 - ions by the fungus Verticillium sp., for the formation of gold nanoparticles is demonstrated. The TEM micrograph shows a single Verticillium cell after reaction with gold ions and entrapment of gold nanoparticles on the cell wall and cytoplasmic membrane.

Intracellular synthesis of gold nanoparticles by a novel alkalotolerant actinomycete, Rhodococcus species

Abstract: The development of reliable, eco-friendly processes for the synthesis of nanoscale materials is an important aspect of nanotechnology. In this paper, we report on the use of an alkalotolerant actinomycete (Rhodococcus sp.) in the intracellular synthesis of gold nanoparticles of the dimension 5–15 nm. Electron microscopy analysis of thin sections of the gold actinomycete cells indicated that gold particles with good monodispersity were formed on the cell wall as well as on the cytospasmic membrane. The particles are more concentrated on the cytoplasmic membrane than on the cell wall, possibly due to reduction of the metal ions by enzymes present in the cell wall and on the cytoplasmic membrane. The metal ions were not toxic to the cells and the cells continued to multiply after biosynthesis of the gold nanoparticles.