Patent
Method and multiple reservoir apparatus for fabrication of biomolecular arrays
TLDR
In this article, a plurality of orifices in an orifice member, at least six delivery chambers each in fluid-conducting relationship with at least one of the ORVMs, and at least two ORVs commonly venting at least three of the reservoirs.Abstract:
Methods and apparatus for delivering a plurality of different biological materials onto discrete locations on a receiving surface, as for example to fabricate an array of different biological materials. The apparatus and methods may include a plurality of orifices in an orifice member, at least six delivery chambers each in fluid conducting relationship with at least one of the orifices, a plurality of reservoirs each in fluid communication with at least one of the delivery chambers, means associated with each orifice for propelling fluid through the associated orifice from the delivery chamber that is in fluid conducting relationship with the orifice, and a vent for commonly venting at least two of the reservoirs. In some embodiments the chambers and reservoirs are loaded with fluids containing selected biomolecules by drawing the selected fluids into the chambers through the orifices; in other embodiments the fluids are introduced into the reservoirs. Also, methods for depositing biological materials onto a surface, as for example to fabricate a biomolecular array, employ the apparatus.read more
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Patent
Substrate preparation process
Martin J. Goldberg,Martin Diggelman,Earl Hubbell,Glenn H. McGall,Nam Quoc Ngo,Macdonald S. Morris,Melvin Yamamoto,Jennifer Tan,Richard P. Rava +8 more
TL;DR: In this article, the authors proposed a method for large scale preparation of arrays of polymer sequences, where each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences.
Patent
Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
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TL;DR: In this paper, the fluid interface port is used to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the micro channel.
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Method for selecting a candidate drug compound
TL;DR: In this article, a method for selecting a candidate drug compound, comprising providing a library of compounds according to the invention and determining the binding of a target molecule to said compounds, is presented.
References
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Patent
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