Patent
Method for manufacturing liposomes
Marina Adamich,David T. Bach +1 more
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TLDR
In this article, a method and apparatus for manufacturing liposomes is characterized by optically monitoring the light transmission of a liposome precursor solution and controlling the flow rate and/or temperature of the precursor solution.Abstract:
A method and apparatus for manufacturing liposomes is characterized by optically monitoring the light transmission of a liposome precursor solution and controlling the flow rate and/or temperature of the precursor solution and/or a dialysis buffer solution in accordance therewith.read more
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Journal ArticleDOI
Targeting tacrolimus to deeper layers of skin with improved safety for treatment of atopic dermatitis.
TL;DR: T-LN displayed superior performance, effective skin targeting and improved safety as compared to reference, and showed significantly higher drug levels penetrating into deeper skin layers where dendritic cells responsible for immunopathogenesis of AD mainly reside.
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High drug:lipid formulations of liposomal antineoplastic agents
TL;DR: In this article, a method for encapsulation of antineoplastic agents in liposomes is provided, having preferably a high drug:lipid ratio, and the method is made by a process that loads the drug by an active mechanism using a transmembrane ion gradient.
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Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases
TL;DR: In this article, a variety of liposomal-digitalis glycoside compositions such as Oleandrin, digitoxin, and digoxin with reduced toxicity, high drug to lipid ratio, long circulating time in the bloodstream and the ability to deliver the drug to tumor sites.
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Polyene macrolide pre-liposomal powders
TL;DR: In this paper, a process for producing fine powder suitable for the preparation of antifungal polyene macrolide-containing liposomes upon suspension in an aqueous solution is described.
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Method of preparing lipid structures
TL;DR: In this paper, a method of forming lipid structures, such as liposomes, was disclosed, in which the water:solvent ratio is raised by removing water and solvent in a reverse osmosis system, and replacing lost solvent with added aqueous medium, preferably at a rate which just balances volume loss by reverse Osmosis.
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Patent
Method of preparing a controlled release liquid pharmaceutical composition
TL;DR: In this article, a pharmaceutical composition is prepared by the steps of dispersing a phospholipid uniformly in water to give an aqueous pharmaceutic dispersion, adding a medicament to the aiquous dispersion and freezing the thus-obtained dispersion to entrap the medicament in the lipid spherules.
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Treatment of cancer with carcinostatic and immunostimulating agent containing lysophospholipid and phospholipid
Yutaka Kodama,Kaoru Oyama,Ryusaku Shimizu,Masao Nakabayashi,Yoshifumi Nakashima,Takashi Sano,Masaaki Shibata,Kiyoshi Goden +7 more
TL;DR: A carcinostatic and immunostimulating agent containing a lysophospholipid and a phospholic acid was used for the treatment of cancerous diseases of the mammals including human being.
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Lipid encapsulated hemoglobin cells
TL;DR: In this paper, the authors used ultrasonic energy to transfer O 2 -CO 2 across the lipid membrane of synthetic erythrocytes, which is of such character and thinness that O 2 --CO 2 transfer thereacross is readily accomplished.
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Apparatus for use in artificial kidney system
TL;DR: In this article, a machine is described for use with an artificial kidney, which has three separately controllable pumps enabling delivery and return of a dialysate solution to an Artificial kidney with precise control of various kidney parameters such as temperature, pressure, conductivity and flow rate.
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Method of and arrangement for producing lipid vesicles
TL;DR: In this paper, a method of and an arrangement for producing lipid vesicles from biological membranes or lipid suspensions, a lipid suspension or lipid particles in a dispersion fluid are accommodated in a treatment container, ultrasonic treatment of the same is performed in condition of a substantially constant temperature.