Yechezkel Barenholz

TL;DR: The ability of pegylated liposomes to extravasate through the leaky vasculature of tumours, as well as their extended circulation time, results in enhanced delivery of liposomal drug and/or radiotracers to the tumour site in cancer patients.

TL;DR: The pharmacokinetics of doxorubicin encapsulated in liposomes containing polyethylene glycol-derivatized distearoylphosphatidylethanolamine (PEG/DSPE) were investigated in rodents and dogs, indicating that drug leakage from circulating liposome is insignificant and that the distribution of liposomal drug is limited mostly to the intravascular compartment in healthy animals.

TL;DR: This Nano Focus presents the main discussion topics and conclusions from a recent workshop: "Mechanisms and Barriers in Nanomedicine", on biological, toxicological, immunological, and translational aspects of nanomedicines and approaches to move the field forward productively.

TL;DR: Very efficient encapsulation of two drugs via their intraliposomal precipitation is presented, the state of encapsulated drug within the liposome is characterized, the experimental data is fitted with a recently developed theoretical model and nice agreement between a model which is based on chemical potential equilibration of membrane permeable species with experimental data was observed.

TL;DR: This review will attempt to address mainly the following issues: interplay of physicochemical parameters of DOTAP formulations; impact of physic biochemical parameters on transfection (lipofection) efficiency by cationic reagents, in vitro and in vivo; structure-activity relationships of cationIC lipid formulations in cell culture and in the living organism.